Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 7/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 7/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | SMURF1 | Q9HCE7 | 1/20 | 0.33 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.33 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27557284 | 0.98 | SLC6A4 (0.35) | SLC6A4SLC6A3L3MBTL1SCN9ASMURF1 | |
| SCHEMBL27492344 | 0.85 | SCN9A (0.35) | SLC6A4SLC6A3SCN9A | |
| SCHEMBL27466734 | 0.75 | HDAC8 (0.38) | SLC6A4SLC6A3HDAC8HDAC6HDAC1 | |
| SCHEMBL27466722 | 0.74 | HDAC8 (0.48) | HDAC8HDAC6HDAC1 | |
| SCHEMBL27466733 | 0.74 | HDAC8 (0.38) | SLC6A4SLC6A3HDAC8HDAC6HDAC1 | |
| SCHEMBL27482758 | 0.73 | MDM2 (0.41) | SLC6A3HDAC8HDAC6HDAC1 | |
| SCHEMBL27466725 | 0.72 | KMT2A (0.45) | L3MBTL1HDAC8HDAC6HDAC1 | |
| SCHEMBL27480883 | 0.70 | HDAC8 (0.51) | SLC6A4SLC6A3HDAC8HDAC6HDAC1 | |
| SCHEMBL2666999 | 0.68 | SLC5A1 (0.40) | L3MBTL1SLC5A1SLC5A2 | |
| SCHEMBL27504948 | 0.67 | HDAC8 (0.38) | SLC6A4SLC6A3L3MBTL1HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1209362-C | Tetrazolyl-phenyl acetamide glucokinase activators | HOFFMANN LA ROCHE (CH) | 2005-07-06 | — | — | CN | disclosed |
| CN-1466584-A | Tetrazolyl-phenyl acetamide glucokinase activators | - | 2004-01-07 | — | — | CN | disclosed |