Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 8/20 | 0.68 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.50 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 7/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.45 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL11375082 | 1.00 | HCAR2 (0.68) | HCAR2KEAP1NFE2L2ALDH1A1ALOX15 | |
| Maleic Acid SCHEMBL27532368 | 0.98 | HCAR2 (0.65) | HCAR2KEAP1NFE2L2ALDH1A1ALOX15 | |
| Maleic Acid SCHEMBL28245132 | 0.98 | HCAR2 (0.65) | HCAR2KEAP1NFE2L2ALDH1A1ALOX15 | |
| Acrylic Acid Methyl Ester SCHEMBL27888603 | 0.90 | LMNA (0.56) | HCAR2KEAP1NFE2L2ALDH1A1ALOX15 | |
| Acrylic Acid Methyl Ester SCHEMBL36950 | 0.90 | LMNA (0.56) | HCAR2KEAP1NFE2L2ALDH1A1ALOX15 | |
| Acrylic Acid Methyl Ester SCHEMBL28195282 | 0.90 | LMNA (0.56) | HCAR2KEAP1NFE2L2ALDH1A1ALOX15 | |
| Acrylic Acid Methyl Ester SCHEMBL14892886 | 0.89 | — | — | |
| Acrylic Acid Methyl Ester SCHEMBL28826007 | 0.89 | HCAR2 (0.56) | HCAR2KEAP1NFE2L2ALDH1A1ALOX15 | |
| Crotonic Acid SCHEMBL28156701 | 0.89 | HCAR2 (0.54) | HCAR2KEAP1NFE2L2ALDH1A1ALOX15 | |
| Acrylic Acid Methyl Ester SCHEMBL27534187 | 0.89 | HCAR2 (0.54) | HCAR2KEAP1NFE2L2ALDH1A1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110023442-A | Resin composition for adhesive and adhesive sheet | 三菱化学株式会社 | 2019-07-16 | — | — | CN | disclosed |
| CN-104507978-B | COLORED PHOTOSENSITIVE COMPOSITION | 株式会社艾迪科 | 2017-03-22 | — | — | CN | disclosed |
| CN-103703063-B | The Porous-Organic granule of crosslinking | 伊斯曼柯达公司 | 2016-06-29 | — | — | CN | disclosed |
| CN-103562304-B | Methacrylic resin composition and molded article | 三井—杜邦聚合化学株式会社 | 2016-06-22 | — | — | CN | disclosed |
| CN-102459757-B | Water-dispersible fiber sheet | UNICHARM CORP | 2014-07-30 | — | — | CN | disclosed |
| CN-102753750-B | Scouring agent composition for fibers | KAO CORP | 2014-07-30 | — | — | CN | disclosed |
| CN-102959432-A | Multilayer optical film | 3M INNOVATIVE PROPERTIES CO | 2013-03-06 | — | — | CN | disclosed |
| CN-102753750-A | Scouring agent composition for fibers | KAO CORP | 2012-10-24 | — | — | CN | disclosed |
| CN-102459757-A | Water-dispersible fiber sheet | UNICHARM CORP | 2012-05-16 | — | — | CN | disclosed |
| CN-1289734-C | Method of mfg. water disintegratable non-woven fabric and water disintegratable non-woven fabric | UNI CHARM CORP (JP) | 2006-12-13 | — | — | CN | disclosed |
| CN-1198658-C | Hydrated fibre sheet of fibrillated artificial fibre containing different length fibre | UNI CHARM CORP (JP) | 2005-04-27 | — | — | CN | disclosed |
| CN-1169484-C | Hydrolysable fibrous sheet containing gel compound | ���ݼѹɷ�����˾ | 2004-10-06 | — | — | CN | disclosed |
| CN-1162117-C | Multi-layer structure hydrolytic wiping sheet | 尤妮佳股份有限公司 | 2004-08-18 | — | — | CN | disclosed |
| CN-1515741-A | Hydrolytic rag with multilayer structure | 尤妮佳股份有限公司 | 2004-07-28 | — | — | CN | disclosed |
| CN-1485252-A | Compound vessel and adhesive for use, decomposition method for cpmpound vessel | 上海高雅玻璃有限公司 | 2004-03-31 | — | — | CN | disclosed |
| CN-1318339-A | Multi-layer structure hydrolytic wiping sheet | UNI CHARM CORP (JP) | 2001-10-24 | — | — | CN | disclosed |
| CN-1315209-A | Hydrated fibre sheet of fibrillated artificial fibre containing different length fibre | UNI CHARM CORP (JP) | 2001-10-03 | — | — | CN | disclosed |
| CN-1315597-A | Hydrofiber sheet with multi-layer structure | UNI CHARM CORP (JP) | 2001-10-03 | — | — | CN | disclosed |
| CN-1304707-A | Hydrolysable fibrous sheet containing gel compound | UNI CHARM CORP (JP) | 2001-07-25 | — | — | CN | disclosed |
| CN-1233677-A | Method of mfg. water disintegratable non-woven fabric and water disintegratable non-woven fabric | UNI CHARM CORP (JP) | 1999-11-03 | — | — | CN | disclosed |