Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK1D | P48730 | 9/20 | 0.39 |
| ▸ | CSNK1E | P49674 | 9/20 | 0.39 |
| ▸ | MET | P08581 | 8/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.39 |
| ▸ | KDR | P35968 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL251105 | 0.93 | GSK3B (0.41) | CSNK1DCSNK1EMETPDE3BPDE3A | |
| SCHEMBL2748206 | 0.91 | MET (0.47) | CSNK1DCSNK1EMETPDE3BPDE3A | |
| SCHEMBL252249 | 0.88 | GSK3B (0.47) | CSNK1DCSNK1EMETPDE3BPDE3A | |
| SCHEMBL252697 | 0.87 | KDR (0.39) | CSNK1DCSNK1EMETPDE3BPDE3A | |
| SCHEMBL253861 | 0.85 | CCNC (0.44) | CSNK1DCSNK1EMETPDE3BPDE3A | |
| SCHEMBL5955382 | 0.85 | CSNK1D (0.37) | CSNK1DCSNK1EMETPDE3BPDE3A | |
| SCHEMBL5955282 | 0.81 | CSNK1D (0.42) | CSNK1DCSNK1EKDR | |
| SCHEMBL251936 | 0.81 | CSNK1D (0.45) | CSNK1DCSNK1EMETKDR | |
| SCHEMBL5954598 | 0.81 | PIK3CA (0.45) | CSNK1DCSNK1EMETKDR | |
| SCHEMBL253143 | 0.80 | KDR (0.46) | CSNK1DCSNK1EMETKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130315895-A1 | COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-11-28 | — | — | US | disclosed |
| EP-2588107-A1 | COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET | Takeda Pharmaceutical Company Limited (JP) | 2013-05-08 | — | — | EP | disclosed |
| US-8178534-B2 | cMET inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-05-15 | — | — | US | disclosed |
| WO-2012003338-A1 | COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-01-05 | — | — | WO | disclosed |
| US-20100063054-A1 | cMET INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-03-11 | — | — | US | disclosed |
| WO-2010019899-A1 | cMET INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-02-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130315895-A1 | COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET | HGF, MET, HGFAC | CSNK1D 2737/4885CSNK1E 1156/4885MET 2/4885 |
| US-20100063054-A1 | cMET INHIBITORS | CEPT1, LCAT, GNMT | CSNK1D 225/4885CSNK1E 119/4885MET 86/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.