Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.33 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.30 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.30 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27494961 | 0.75 | — | — | |
| SCHEMBL27478874 | 0.73 | RAB9A (0.37) | KMT2AKDM4E | |
| SCHEMBL27479658 | 0.71 | KDM4E (0.33) | KDM4E | |
| SCHEMBL27478872 | 0.71 | ALDH1A1 (0.35) | KMT2AKDM4E | |
| SCHEMBL27478044 | 0.71 | NPC1 (0.35) | KMT2AKDM4E | |
| SCHEMBL30161783 | 0.70 | KDM4E (0.33) | KDM4E | |
| SCHEMBL27529957 | 0.69 | THRB (0.33) | — | |
| SCHEMBL7922195 | 0.65 | ADORA2A (0.37) | NTRK1KDM4ECNR2 | |
| SCHEMBL27769281 | 0.65 | ALOX5 (0.30) | — | |
| SCHEMBL27968914 | 0.63 | ALDH1A1 (0.33) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1175256-A | tetracyclic spiro compounds, process for their preparation and their use as 5HT1D receptor antagonists | SMITHKLINE BEECHAM PLC (GB) | 1998-03-04 | — | — | CN | disclosed |