Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 4/20 | 0.55 |
| ▸ | CDK2 | P24941 | 4/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | MGAM | O43451 | 1/20 | 0.47 |
| ▸ | SI | P14410 | 1/20 | 0.47 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27477020 | 0.88 | NPC1 (0.51) | CCNA2CDK2RAB9AGAAPOLB | |
| SCHEMBL27478332 | 0.86 | CCNA2 (0.61) | CCNA2CDK2RAB9AGAAMGAM | |
| SCHEMBL874739 | 0.83 | RAB9A (0.71) | CCNA2CDK2RAB9AGAAMGAM | |
| SCHEMBL27609568 | 0.82 | CCNA2 (0.53) | CCNA2CDK2RAB9AGAAPOLB | |
| SCHEMBL27609672 | 0.81 | CCNA2 (0.56) | CCNA2CDK2RAB9AGAAPOLB | |
| SCHEMBL27591227 | 0.80 | CDC7 (0.53) | CCNA2CDK2RAB9AGAAPOLB | |
| SCHEMBL27762075 | 0.80 | MEN1 (0.58) | CCNA2CDK2RAB9AMAPK1ALDH1A1 | |
| SCHEMBL9189648 | 0.76 | LMNA (0.72) | GAAPOLBMAPK1ALDH1A1KMT2A | |
| SCHEMBL27464786 | 0.75 | CCNA2 (0.51) | CCNA2CDK2RAB9AGAAPOLB | |
| SCHEMBL27591223 | 0.73 | CDK5 (0.58) | CCNA2CDK2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1158269-C | 4-aminothiazole derivs, their preparation and their use as inhibitors of cyclin-dependent kinases | ������ҩ������˾ | 2004-07-21 | — | — | CN | disclosed |
| CN-1276789-A | 4-aminothiazole derivatives, their preparation and their use as inhibitors of cyclin dependent kinases | AGOURON PHARMA (US) | 2000-12-13 | — | — | CN | disclosed |