Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | PPARA | Q07869 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | PPARG | P37231 | 2/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | GRM6 | O15303 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzene SCHEMBL27546891 | 0.83 | KMT2A (0.39) | KMT2AMAPTTSHRMEN1CYP2C19 | |
| 4-Chloroaniline SCHEMBL27831633 | 0.83 | MAOA (0.44) | KMT2AMAPTPPARAMEN1CYP3A4 | |
| Aniline SCHEMBL27495165 | 0.82 | TSHR (0.44) | KMT2AMAPTTSHRMEN1CYP3A4 | |
| Toluene SCHEMBL26697033 | 0.82 | TSHR (0.44) | KMT2AMAPTTSHRMEN1CYP3A4 | |
| SCHEMBL27890515 | 0.81 | MEN1 (0.42) | KMT2AMAPTTSHRPPARAMEN1 | |
| Aniline SCHEMBL28104783 | 0.81 | KMT2A (0.42) | KMT2AMAPTTSHRMEN1CYP3A4 | |
| Benzoic Acid SCHEMBL999801 | 0.81 | TSHR (0.54) | KMT2AMAPTTSHRCYP3A4CYP2C19 | |
| Fluorobenzene SCHEMBL27926129 | 0.81 | KCNN4 (0.46) | KMT2AMAPTTSHRMEN1ALDH1A1 | |
| Benzamide SCHEMBL5320681 | 0.81 | PARP1 (0.61) | KMT2AMAPTTSHRCYP3A4CYP2C19 | |
| SCHEMBL28807393 | 0.80 | MEN1 (0.49) | KMT2AMAPTTSHRPPARAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101965351-A | Benzofuran pyrimidinones | EXELIXIS INC | 2011-02-02 | — | — | CN | disclosed |
| CN-1224623-C | 1-phenylsulfonyl-1, 3-dihydro-2H-indol-2-one derivatives, their preparation and their therapeutic use | SANOFI ANWANTE (FR) | 2005-10-26 | — | — | CN | disclosed |
| CN-1193025-C | 1, 3-dihydro-2H-indol-2-one derivatives, process for their preparation and pharmaceutical compositions containing them | SANOFI SYNTHELABO (FR) | 2005-03-16 | — | — | CN | disclosed |
| CN-1533387-A | 1-phenysulfonyl-1,3-dihydro-2H-indole-2-one derivatives, their preparation and their therapeutic use | ����ɳŵ��-����������˾ | 2004-09-29 | — | — | CN | disclosed |
| CN-1404479-A | 1, 3-dihydro-2H-indol-2-one derivatives, process for their preparation and pharmaceutical compositions containing them | SANOFI SYNTHELABO (FR) | 2003-03-19 | — | — | CN | disclosed |