Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDPP4HTR1BHTR1D
The experimentally established mechanism targets of Benzoic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.54 |
| ▸ | DAO | P14920 | 1/20 | 0.54 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | SRD5A2 | P31213 | 3/20 | 0.47 |
| ▸ | CES2 | O00748 | 1/20 | 0.47 |
| ▸ | CES1 | P23141 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzamide SCHEMBL5320681 | 0.89 | PARP1 (0.61) | TSHRHSD17B10TDP1ALDH1A1MAPT | |
| Benzene SCHEMBL27546891 | 0.83 | KMT2A (0.39) | TSHRHSD17B10TDP1ALDH1A1MAPT | |
| Aniline SCHEMBL27495165 | 0.82 | TSHR (0.44) | TSHRHSD17B10TDP1ALDH1A1MAPT | |
| Toluene SCHEMBL26697033 | 0.82 | TSHR (0.44) | TSHRHSD17B10TDP1ALDH1A1CES2 | |
| Benzoic Acid SCHEMBL28984654 | 0.82 | TSHR (0.58) | TSHRDAONAPRTHSD17B10TDP1 | |
| Benzoic Acid SCHEMBL28735573 | 0.81 | TSHR (0.50) | TSHRDAONAPRTHSD17B10TDP1 | |
| SCHEMBL7276303 | 0.81 | ALDH1A1 (0.65) | TDP1ALDH1A1MAPTKMT2ARXRA | |
| Aniline SCHEMBL28104783 | 0.81 | KMT2A (0.42) | TSHRHSD17B10TDP1ALDH1A1MAPT | |
| Chlorobenzene SCHEMBL27484099 | 0.81 | KMT2A (0.42) | TSHRHSD17B10TDP1ALDH1A1CES2 | |
| Fluorobenzene SCHEMBL27926129 | 0.81 | KCNN4 (0.46) | TSHRHSD17B10TDP1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117567537-A | Synthesis and use of reversible termination nucleotide based on pH sensitive connecting unit | 上海交通大学 | 2024-02-20 | — | — | CN | claimed |
| CN-117567537-A | Synthesis and use of reversible termination nucleotide based on pH sensitive connecting unit | 上海交通大学 | 2024-02-20 | — | — | CN | disclosed |
| US-7868135-B2 | Compositions of lipopeptide antibiotic derivatives and methods of use thereof | BIOWEST THERAPEUTICS INC. (CA) | 2011-01-11 | — | — | US | disclosed |
| EP-2147925-A1 | Compositions of lipopeptide antibiotic derivatives and methods of use thereof | MIGENIX INC. (CA) | 2010-01-27 | — | — | EP | disclosed |
| US-20050153876-A1 | Compositions of lipopeptide antibiotic derivatives and methods of use thereof | MIGENIX INC. (CA) | 2005-07-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050153876-A1 | Compositions of lipopeptide antibiotic derivatives and methods of use thereof | NRDC, NOD2, NGLY1 | TSHR 3091/4885DAO 602/4885NAPRT 2042/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.