Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.36 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ACLY | P53396 | 1/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7927986 | 0.88 | CDC7 (0.43) | CDC7RORCPRMT5CYP11B2ENPP3 | |
| SCHEMBL7856860 | 0.84 | KDM4E (0.43) | CDC7RORCCYP11B2ENPP3KDM4E | |
| SCHEMBL25766341 | 0.78 | HTR2A (0.43) | CDC7PRMT5ENPP3KDM4EALDH1A1 | |
| SCHEMBL565952 | 0.78 | HTR7 (0.38) | CYP11B2HTR2AHTR7KDM4C | |
| SCHEMBL25766275 | 0.77 | HTR6 (0.39) | CDC7PRMT5ENPP3KDM4EALDH1A1 | |
| SCHEMBL12391648 | 0.76 | NOS3 (0.49) | RORCHRH3HTR2AHTR7P2RX7 | |
| SCHEMBL20340238 | 0.76 | CDC7 (0.46) | CDC7RORCPRMT5CYP11B2KDM4E | |
| SCHEMBL20837893 | 0.75 | CYP11B2 (0.39) | CYP11B2CA1CA2 | |
| SCHEMBL30808812 | 0.75 | CDC7 (0.38) | CDC7RORCCYP11B2ENPP3KDM4E | |
| SCHEMBL28985534 | 0.72 | CDC7 (0.36) | CDC7PRMT5ENPP3KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1166636-C | Arylpiperazinyl-cyclohexylindole derivatives for the treatment of depression | — | 2004-09-15 | — | — | CN | disclosed |
| CN-1336916-A | Arylpiperazinyl-cyclohexyl indole derivatives for the treatment of depression | AMERICAN HOME PROD (US) | 2002-02-20 | — | — | CN | disclosed |