Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 4/20 | 0.54 |
| ▸ | SIGMAR1 known ✓ | Q99720 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.54 |
| ▸ | LMNA | P02545 | 5/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Butetamate SCHEMBL317018 | 0.73 | KDM4E (1.00) | KDM4EMAPTCYP2D6LMNACYP1A2 | |
| SCHEMBL9325583 | 0.72 | KDM4E (0.64) | KDM4EMAPTCYP2D6LMNACYP1A2 | |
| Citric Acid SCHEMBL9324866 | 0.71 | KDM4E (0.56) | KDM4EMAPTCYP2D6LMNACYP1A2 | |
| Alverine SCHEMBL352008 | 0.70 | KDM4E (1.00) | KDM4EMAPTCYP2D6LMNACYP1A2 | |
| Butamirate SCHEMBL636120 | 0.70 | KDM4E (0.88) | KDM4EMAPTCYP2D6LMNACYP1A2 | |
| Citric Acid SCHEMBL8614814 | 0.70 | KMT2A (0.89) | KDM4EMAPTCYP2D6LMNACYP1A2 | |
| Citric Acid SCHEMBL8616232 | 0.70 | KMT2A (0.89) | KDM4EMAPTCYP2D6LMNACYP1A2 | |
| Citric Acid SCHEMBL8614802 | 0.70 | KMT2A (0.89) | KDM4EMAPTCYP2D6LMNACYP1A2 | |
| Citric Acid SCHEMBL9325567 | 0.70 | CYP1A2 (0.56) | KDM4EMAPTCYP2D6LMNACYP1A2 | |
| Citric Acid SCHEMBL9323625 | 0.70 | CHRM2 (0.53) | KDM4EMAPTCYP2D6LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1167437-A | Method of using triaryl-ethylene derivatives in the treatment and prevention of osteoporosis | HOECHST MARION ROUSSEL INC (US) | 1997-12-10 | — | — | CN | disclosed |