Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIN1 | Q13526 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.38 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | IKBKB | O14920 | 1/20 | 0.38 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | PAK4 | O96013 | 1/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2098363 | 0.89 | PIN1 (0.58) | PIN1NUDT1CDK5TAOK1CLK4 | |
| SCHEMBL23481321 | 0.88 | CA1 (0.45) | PIN1SMN1; SMN2NUDT1ALDH1A1RAB9A | |
| SCHEMBL2749668 | 0.87 | PIN1 (0.56) | PIN1NUDT1ALDH1A1CDK5TAOK1 | |
| SCHEMBL2749274 | 0.87 | PIN1 (0.56) | PIN1SMN1; SMN2NUDT1RAB9ACDK5 | |
| SCHEMBL18573848 | 0.84 | SMN1; SMN2 (0.46) | PIN1SMN1; SMN2NUDT1ALDH1A1RAB9A | |
| SCHEMBL2747687 | 0.83 | PIN1 (0.56) | PIN1NUDT1CDK5TAOK1CLK4 | |
| SCHEMBL18573951 | 0.82 | SMN1; SMN2 (0.47) | SMN1; SMN2NUDT1ALDH1A1RAB9AMEN1 | |
| SCHEMBL13845558 | 0.82 | TPSAB1 (0.48) | SMN1; SMN2NUDT1ALDH1A1RAB9AMEN1 | |
| SCHEMBL20434695 | 0.81 | ERCC1 (0.44) | SMN1; SMN2NUDT1ALDH1A1RAB9A | |
| SCHEMBL15483861 | 0.81 | ALDH1A1 (0.49) | SMN1; SMN2NUDT1ALDH1A1RAB9AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874738-B1 | PYRIMIDINES REACTING WITH O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE | COVALYS BIOSCIENCES AG (CH) | 2016-06-29 | — | — | EP | disclosed |
| US-8178314-B2 | Pyrimidines reacting with O6-alkylguanine-DNA alkyltransferase fusion protein and method for detecting protein | COVALYS BIOSCIENCES AG (CH) | 2012-05-15 | — | — | US | disclosed |
| US-20090186373-A1 | Pyrimidines reacting with O6-Alkylguanine-DNA alkyltransferase | COVALYS BIOSCIENCES AG (CH) | 2009-07-23 | — | — | US | disclosed |
| EP-1874738-A1 | PYRIMIDINES REACTING WITH O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE | Covalys Biosciences AG (CH) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006114409-A9 | PYRIMIDINES REACTING WITH O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE | COVALYS BIOSCIENCES AG (CH) | 2007-10-18 | — | — | WO | disclosed |
| WO-2006114409-A1 | PYRIMIDINES REACTING WITH O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE | COVALYS BIOSCIENCES AG (CH) | 2006-11-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090186373-A1 | Pyrimidines reacting with O6-Alkylguanine-DNA alkyltransferase | HPRT1, UNG, DPYD | PIN1 2835/4885SMN1; SMN2 4497/4885NUDT1 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.