SCHEMBL2748892

SCHEMBL2748892

Nc1nc2c(Br)cccc2s1

nearest known ligand 0.61

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.61
LMNA P02545 2/20 0.61
SMN1; SMN2 Q16637 2/20 0.61
PDPK1 O15530 1/20 0.61
PDE10A Q9Y233 1/20 0.61
CYP3A4 P08684 1/20 0.56
TDP1 Q9NUW8 1/20 0.56
MAPT P10636 2/20 0.46
L3MBTL1 Q9Y468 1/20 0.46
BACE1 P56817 1/20 0.46
NSD1 Q96L73 1/20 0.44
HSD17B10 Q99714 2/20 0.39
RAB9A P51151 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3258678 0.81 MAPT (0.50) ALDH1A1LMNASMN1; SMN2PDPK1PDE10A
SCHEMBL18273024 0.80 ALDH1A1 (0.49) ALDH1A1LMNASMN1; SMN2PDPK1PDE10A
SCHEMBL969167 0.79 ALDH1A1 (0.66) ALDH1A1LMNASMN1; SMN2PDPK1PDE10A
SCHEMBL28018647 0.78 LMNA (0.56) ALDH1A1LMNASMN1; SMN2PDPK1PDE10A
Hydrochloric Acid SCHEMBL28787382 0.78 ALDH1A1 (0.63) ALDH1A1LMNASMN1; SMN2PDPK1PDE10A
SCHEMBL24858578 0.76 ALDH1A1 (0.61) ALDH1A1LMNASMN1; SMN2PDPK1PDE10A
SCHEMBL2749466 0.76 ALDH1A1 (0.56) ALDH1A1LMNASMN1; SMN2PDPK1PDE10A
SCHEMBL2750562 0.76 MAPT (0.46) ALDH1A1LMNASMN1; SMN2PDPK1PDE10A
SCHEMBL103727 0.76 LMNA (1.00) ALDH1A1LMNASMN1; SMN2PDPK1PDE10A
SCHEMBL102844 0.76 SMN1; SMN2 (1.00) ALDH1A1LMNASMN1; SMN2PDPK1PDE10A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 139 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107417705-B Imidazo [2,1-b] benzothiazole compound and its synthetic method 湘潭大学 2019-07-02 CN claimed
CN-107417705-A Imidazo [2,1 b] benzothiazole compound and its synthetic method 湘潭大学 2017-12-01 CN claimed
CN-119528901-B Thiazole compound, dessumo and/or deubiquitinase inhibitor, and preparation methods and applications thereof Shanghai tongji hospital (CN) 2026-05-26 CN disclosed
US-20260062425-A1 AZA-TETRACYCLIC OXAZEPINE COMPOUNDS AND USES THEREOF GENENTECH INC (US) 2026-03-05 US disclosed
EP-4652154-A1 NOVEL ALPK1 INHIBITORS Pyrotech (Beijing) Biotechnology Co., Ltd. (CN) 2025-11-26 EP disclosed
EP-4631948-A1 NOVEL TRICYCLIC COMPOUND AS KRAS G12D INHIBITOR, AND USE THEREOF SK Biopharmaceuticals Co., Ltd. (KR) 2025-10-15 EP disclosed
EP-4626888-A1 COMPOUNDS Redx Pharma Limited (GB) 2025-10-08 EP disclosed
EP-4606803-A1 KRAS G12D DEGRADATION AGENT, AND PREPARATION METHOD AND USE THEREFOR Leadingtac Pharmaceutical (Shaoxing) Co., Ltd. (CN) 2025-08-27 EP disclosed
US-12365676-B2 Heterocyclic compounds and uses thereof KUMQUAT BIOSCIENCES INC. (US) 2025-07-22 US disclosed
US-12338256-B2 Aza-tetracyclic oxazepine compounds and uses thereof GENENTECH, INC. (US) 2025-06-24 US disclosed
EP-4554580-A1 NEW ANTIBIOTIC COMPOUNDS Université Côte d'Azur (FR) 2025-05-21 EP disclosed
US-5635607-A BLUE OR VIOLET COLOR DYE FOR DYEING PAPER, TEXTILES CIBA-GEIGY CORPORATION (US) 1997-06-03 US disclosed
EP-0679691-A2 Cationic or basic aminobenzthiazole dyestuffs CIBA-GEIGY AG (CH) 1995-11-02 EP disclosed
US-5424439-A Process for the preparation of 2-amino-4-nitrobenzothiazole derivatives and intermediates RHONE-POULENC RORER S.A. (FR) 1995-06-13 US disclosed
US-5120872-A Textile dyeing CIBA-GEIGY CORPORATION (US) 1992-06-09 US disclosed
US-4994563-A Dyeing, printing cellulose, silk, wool, synthetic polyamides; colorfastness CIBA-GEIGY CORPORATION (US) 1991-02-19 US disclosed
EP-0349486-A2 Azo dyes, their preparation and their use CIBA-GEIGY AG (CH) 1990-01-03 EP disclosed
US-4118384-A DIAZOTIZATION BAYER AKTIENGESELLSCHAFT (DE) 1978-10-03 US disclosed
US-4041024-A FOR POLYAMIDES AND POLYURETHANES BAYER AKTIENGESELLSCHAFT (DT) 1977-08-09 US disclosed
US-3933423-A Azoic dyeing of leather E. I. DU PONT DE NEMOURS AND COMPANY (US) 1976-01-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12338256-B2 Aza-tetracyclic oxazepine compounds and uses thereof AZI2, TET3, OXA1L ALDH1A1 1000/4885LMNA 4245/4885SMN1; SMN2 2361/4885
US-12365676-B2 Heterocyclic compounds and uses thereof TP53, KRAS, HRAS ALDH1A1 3377/4885LMNA 2529/4885SMN1; SMN2 1460/4885
US-20260062425-A1 AZA-TETRACYCLIC OXAZEPINE COMPOUNDS AND USES THEREOF KRAS, NRAS, HRAS ALDH1A1 908/4885LMNA 3592/4885SMN1; SMN2 1998/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.