SCHEMBL3258678

SCHEMBL3258678

Brc1nc2c(Br)cccc2s1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.50
L3MBTL1 Q9Y468 1/20 0.50
CASP3 P42574 1/20 0.42
SENP8 Q96LD8 1/20 0.42
SENP7 Q9BQF6 1/20 0.42
SENP6 Q9GZR1 1/20 0.42
ALDH1A1 P00352 6/20 0.41
GAA P10253 5/20 0.41
LMNA P02545 4/20 0.41
MEN1 O00255 4/20 0.41
KMT2A Q03164 4/20 0.41
HPGD P15428 3/20 0.41
SMN1; SMN2 Q16637 3/20 0.41
KDM4E B2RXH2 3/20 0.41
NPC1 O15118 2/20 0.41
RAB9A P51151 2/20 0.41
PRNP P04156 1/20 0.41
BACE1 P56817 1/20 0.41
TDP1 Q9NUW8 2/20 0.39
MAPK1 P28482 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2750562 0.81 MAPT (0.46) MAPTL3MBTL1CASP3SENP8SENP7
SCHEMBL16975214 0.81 MAPT (0.46) MAPTL3MBTL1CASP3SENP8SENP7
SCHEMBL13479872 0.81 MAPT (0.46) MAPTL3MBTL1CASP3SENP8SENP7
SCHEMBL2749466 0.81 ALDH1A1 (0.56) MAPTL3MBTL1CASP3SENP8SENP7
SCHEMBL2748892 0.81 ALDH1A1 (0.61) MAPTL3MBTL1ALDH1A1LMNASMN1; SMN2
SCHEMBL3918916 0.78 ALDH1A1 (0.63) MAPTL3MBTL1ALDH1A1GAALMNA
SCHEMBL9799782 0.78 PSMD14 (0.41) MAPTL3MBTL1ALDH1A1GAALMNA
SCHEMBL3077601 0.78 SMN1; SMN2 (0.67) MAPTL3MBTL1CASP3SENP8SENP7
SCHEMBL14127197 0.78 ALDH1A1 (0.63) MAPTL3MBTL1ALDH1A1GAALMNA
SCHEMBL2433144 0.78 LMNA (0.63) MAPTCASP3SENP8SENP7SENP6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105198834-B The synthesis technique of 2,6 dibromo benzothiazoles 上海泰坦科技股份有限公司 2017-09-29 CN claimed
CN-118146263-A Dinitrile ethylene and triphenylphosphine end capped quinoid compound and preparation method and application thereof 中国科学院化学研究所 2024-06-07 CN disclosed
CN-105198834-A Synthesizing process of 2, 6-dibromo benzothiazole SHANGHAI TITAN TECHNOLOGY CO LTD 2015-12-30 CN disclosed
US-7651746-B2 Halogenated bisdiarylaminopolycyclic aromatic compounds and polymers thereof SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2010-01-26 US disclosed
US-20070126345-A1 Halogenated bisdiarylaminopolycylic aromatic compounds and polymers thereof SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2007-06-07 US disclosed
WO-2005049546-A1 HALOGENATED BISDIARYLAMINOPOLYCYLIC AROMATIC COMPOUNDS AND POLYMERS THEREOF SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2005-06-02 WO disclosed
EP-0175641-B1 PROCESS FOR THE PREPARATION OF DIMETHYLMALEIC ANHYDRIDE CIBA-GEIGY AG (CH) 1988-02-24 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070126345-A1 Halogenated bisdiarylaminopolycylic aromatic compounds and polymers thereof AHR, AADAC, ARNT MAPT 2098/4885L3MBTL1 1104/4885CASP3 2079/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.