Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 5/20 | 0.38 |
| ▸ | PPARA | Q07869 | 5/20 | 0.38 |
| ▸ | PTGES | O14684 | 4/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3632860 | 0.87 | TDP1 (0.44) | L3MBTL1ALDH1A1CYP1A2CASP1PPARG | |
| Methyl Alcohol SCHEMBL27966192 | 0.85 | ADRB2 (0.43) | L3MBTL1ALDH1A1CYP1A2CASP1PPARG | |
| Water SCHEMBL27298765 | 0.85 | L3MBTL1 (0.43) | L3MBTL1ALDH1A1CYP1A2CASP1PPARG | |
| SCHEMBL27517150 | 0.80 | CASP1 (0.42) | L3MBTL1ALDH1A1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL17502798 | 0.79 | TDP1 (0.49) | L3MBTL1ALDH1A1CYP1A2PPARGTDP1 | |
| SCHEMBL3939804 | 0.79 | TDP1 (0.49) | L3MBTL1ALDH1A1CYP1A2PPARGTDP1 | |
| SCHEMBL30605965 | 0.79 | TDP1 (0.49) | L3MBTL1ALDH1A1CYP1A2PPARGTDP1 | |
| SCHEMBL6537087 | 0.79 | POLB (0.59) | POLBMAPTL3MBTL1MEN1KMT2A | |
| SCHEMBL28057308 | 0.78 | POLB (0.46) | POLBMAPTL3MBTL1MEN1KMT2A | |
| SCHEMBL1837507 | 0.77 | POLB (0.57) | POLBMAPTL3MBTL1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105579457-A | Substituted N-biphenyl-3-acetylamino-benzamides and N- [3- (acetylamino) phenyl ] -biphenyl-carboxamides and their use as WNT signaling pathway inhibitors | Bayer Pharma AG | 2016-05-11 | — | — | CN | disclosed |
| CN-105037326-A | Aryl- and heteroarylcarbonyl derivatives of hexahydroindenopyridine and octahydrobenzoquinoline | VITAE PHARMACEUTICALS INC | 2015-11-11 | — | — | CN | disclosed |
| CN-102666491-B | Aryl-and heteroarylcarbonyl derivatives of hexahydroindenopyridine and octahydrobenzoquinoline | VITAE PHARMACEUTICALS INC | 2015-06-24 | — | — | CN | disclosed |
| CN-103228642-B | Crystalline forms of hydrochloride salt of (4a-,9a-s)-1-(1h-benzoimidazole-5-carbonyl)-2,3,4,4a,9,9a-hexahydro-1h-indeno[2,1-b]pyridine-6-carbonitrile and their use as HSD 1 inhibitors | BOEHRINGER INGELHEIM INT | 2015-02-18 | — | — | CN | disclosed |
| CN-103228642-A | Crystalline forms of hydrochloride salt of (4a-,9a-s)-1-(1h-benzoimidazole-5-carbonyl)-2,3,4,4a,9,9a-hexahydro-1h-indeno[2,1-b]pyridine-6-carbonitrile and their use as HSD 1 inhibitors | BOEHRINGER INGELHEIM INT | 2013-07-31 | — | — | CN | disclosed |
| CN-102666491-A | Aryl-and heteroarylcarbonyl derivatives of hexahydroindenopyridine and octahydrobenzoquinoline | VITAE PHARMACEUTICALS INC | 2012-09-12 | — | — | CN | disclosed |
| CN-101100443-B | Process for preparing beta-amino-alpha-hydroxycarboxamides | EVONIK DEGUSSA GMBH | 2012-04-25 | — | — | CN | disclosed |
| CN-101641330-A | Benzamide derivatives and process for preparing the same | DONG A PHARM CO LTD KR | 2010-02-03 | — | — | CN | disclosed |
| CN-101100443-A | Process for preparing beta-amino-alpha-hydroxycarboxamides | DEGUSSA (DE) | 2008-01-09 | — | — | CN | disclosed |
| CN-1233180-A | Treatment of the common cold or allergic rhinitis | LILLY CO ELI (US) | 1999-10-27 | — | — | CN | disclosed |
| CN-1123546-A | 4-arylisoindole analgesics | ORTHO PHARMA CORP (US) | 1996-05-29 | — | — | CN | disclosed |