Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.50 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.50 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.50 |
| ▸ | MMP2 | P08253 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | COMT | P21964 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | METAP2 | P50579 | 1/20 | 0.48 |
| ▸ | METAP1 | P53582 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27751301 | 0.84 | PARP1 (0.62) | PARP1ALDH1A1LMNAALOX12NPC1 | |
| SCHEMBL28050846 | 0.81 | PARP1 (0.72) | PARP1ALDH1A1LMNAALOX12NPC1 | |
| SCHEMBL9449256 | 0.80 | PARP1 (0.57) | PARP1ALDH1A1LMNAALOX12NPC1 | |
| SCHEMBL111826 | 0.79 | PARP1 (0.70) | PARP1ALDH1A1LMNAALOX12NPC1 | |
| SCHEMBL29749881 | 0.79 | PARP1 (0.70) | PARP1ALDH1A1LMNAALOX12NPC1 | |
| SCHEMBL27995395 | 0.79 | MAPT (0.49) | PARP1ALDH1A1LMNAALOX12NPC1 | |
| SCHEMBL16859274 | 0.78 | PARP1 (0.68) | PARP1ALDH1A1LMNAALOX12NPC1 | |
| SCHEMBL1164312 | 0.78 | PARP1 (0.68) | PARP1ALDH1A1LMNAALOX12NPC1 | |
| SCHEMBL4507521 | 0.78 | PARP1 (0.68) | PARP1ALDH1A1LMNAALOX12NPC1 | |
| Hydrochloric Acid SCHEMBL7320778 | 0.78 | PARP1 (0.68) | PARP1ALDH1A1LMNAALOX12NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108299415-B | Quinolinequinone derivative and preparation method and application thereof | 南通大学 | 2020-11-10 | — | — | CN | claimed |
| CN-108299415-A | A kind of quinoline quinone derivative and preparation method and purposes | 南通大学 | 2018-07-20 | — | — | CN | claimed |
| CN-100519533-C | 5-arylamino quinolyl-7,8-dione derivative and its application in preparing antibiotic medicine | UNIV GUANGDONG TECHNOLOGY (CN) | 2009-07-29 | — | — | CN | claimed |
| CN-1974557-A | 5-arylamino quinolyl-7,8-dione derivative and its application in preparing antibiotic medicine | UNIV GUANGDONG POLYTECHNIC (CN) | 2007-06-06 | — | — | CN | claimed |
| CN-113214149-B | Synthesis method of phenyl (quinoline-8-yl) ketone derivative | 江苏师范大学 | 2022-08-02 | — | — | CN | disclosed |
| CN-113214149-A | Synthesis method of phenyl (quinoline-8-yl) ketone derivative | 江苏师范大学 | 2021-08-06 | — | — | CN | disclosed |
| CN-108299415-B | Quinolinequinone derivative and preparation method and application thereof | 南通大学 | 2020-11-10 | — | — | CN | disclosed |
| CN-110218198-A | A kind of naphthoquinones and triazole core skeleton derivative compound and its preparation method and application | 广州中医药大学(广州中医药研究院) | 2019-09-10 | — | — | CN | disclosed |
| CN-109020986-A | Quinoline quinone and oxa- ring derivatives and preparation method thereof and the application on anti-tumor drug | 中南大学 | 2018-12-18 | — | — | CN | disclosed |
| CN-108299415-A | A kind of quinoline quinone derivative and preparation method and purposes | 南通大学 | 2018-07-20 | — | — | CN | disclosed |
| CN-100374438-C | Pre-organized tricyclic integrase inhibitor compounds | GILEAD SCIENCES INC (US) | 2008-03-12 | — | — | CN | disclosed |
| CN-1726212-A | Pre-organized tricyclic integrase inhibitor compounds | GILEAD SCIENCES INC (US) | 2006-01-25 | — | — | CN | disclosed |
| CN-1187352-C | Phenanthroline-7-one derivatives and their therapeutic use | LAFON LABOR (FR) | 2005-02-02 | — | — | CN | disclosed |
| CN-1139575-C | Process for preparing quinoline-5, 8-diones | L���������鹫˾ | 2004-02-25 | — | — | CN | disclosed |
| CN-1129582-C | 3-substituted-4-arylquinolin-2-one derivatives as potassium channel modulators | BRISTOL MYERS SQUIBB CO (US) | 2003-12-03 | — | — | CN | disclosed |
| CN-1373761-A | Phenanthroline-7-one derivatives and their therapeutic use | LAFON LABOR (FR) | 2002-10-09 | — | — | CN | disclosed |
| CN-1370149-A | Process for preparing quinoline-5, 8-diones | LAFON LABOR (FR) | 2002-09-18 | — | — | CN | disclosed |
| CN-1344269-A | Pharmaceutical compsn. based on polyaromatic compounds | LAFON LABOR (FR) | 2002-04-10 | — | — | CN | disclosed |
| CN-1329599-A | 3-substituted-4-arylquinolin-2-one derivatives as potassium channel modulators | BRISTOL MYERS SQUIBB CO (US) | 2002-01-02 | — | — | CN | disclosed |