Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | BACE1 | P56817 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5242546 | 0.89 | KMT2A (0.56) | KMT2AMEN1GAAPTGS1PTGS2 | |
| SCHEMBL9535701 | 0.86 | KMT2A (0.54) | KMT2AMEN1GAAPTGS1PTGS2 | |
| SCHEMBL27918191 | 0.83 | GPBAR1 (0.53) | GAATSHRGPBAR1 | |
| SCHEMBL27749853 | 0.81 | PTGS1 (0.55) | KMT2AMEN1GAAPTGS1PTGS2 | |
| SCHEMBL27936779 | 0.80 | GPBAR1 (0.55) | KMT2AMEN1GAAPOLBMAPK1 | |
| SCHEMBL28807437 | 0.80 | GPBAR1 (0.51) | PTGS1TSHRMAPK1GPBAR1SMN1; SMN2 | |
| SCHEMBL27936754 | 0.80 | HSD17B10 (0.59) | GAAPTGS1PTGS2GPBAR1HTT | |
| SCHEMBL28805571 | 0.79 | GPBAR1 (0.46) | KMT2AMEN1PTGS2POLBTSHR | |
| SCHEMBL9535755 | 0.78 | ALDH1A1 (0.52) | GAAPTGS2MAPK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL9535442 | 0.78 | GPBAR1 (0.51) | KMT2AMEN1GAAPOLBTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1222520-C | Inhibitors of c-JUN N-terminal kinase (JNK) and other protein kinases | VERTEX PHARMA (US) | 2005-10-12 | — | — | CN | disclosed |