Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUDT1 | P36639 | 3/20 | 0.51 |
| ▸ | MAOB | P27338 | 7/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.40 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.39 |
| ▸ | LOX | P28300 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1034474 | 0.84 | NUDT1 (0.55) | NUDT1MAOBROCK1 | |
| SCHEMBL21513506 | 0.79 | NUDT1 (0.48) | NUDT1ROCK1 | |
| SCHEMBL359764 | 0.76 | NUDT1 (0.53) | NUDT1 | |
| SCHEMBL21513973 | 0.76 | NUDT1 (0.46) | NUDT1ROCK1 | |
| SCHEMBL2750032 | 0.76 | NUDT1 (0.54) | NUDT1MAOB | |
| SCHEMBL31141585 | 0.76 | SMN1; SMN2 (0.51) | NUDT1MAOBLOXL2LOX | |
| SCHEMBL2749327 | 0.76 | SMN1; SMN2 (0.51) | NUDT1MAOBLOXL2LOX | |
| SCHEMBL21513517 | 0.74 | NUDT1 (0.43) | NUDT1ROCK1 | |
| SCHEMBL28189689 | 0.74 | NUDT1 (0.61) | NUDT1ROCK1 | |
| SCHEMBL2747687 | 0.72 | PIN1 (0.56) | NUDT1ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874738-B1 | PYRIMIDINES REACTING WITH O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE | COVALYS BIOSCIENCES AG (CH) | 2016-06-29 | — | — | EP | disclosed |
| US-8178314-B2 | Pyrimidines reacting with O6-alkylguanine-DNA alkyltransferase fusion protein and method for detecting protein | COVALYS BIOSCIENCES AG (CH) | 2012-05-15 | — | — | US | disclosed |
| US-20090186373-A1 | Pyrimidines reacting with O6-Alkylguanine-DNA alkyltransferase | COVALYS BIOSCIENCES AG (CH) | 2009-07-23 | — | — | US | disclosed |
| WO-2008097190-A1 | METHODS OF ELECTRICALLY DETECTING A NUCLEIC ACID BY MEANS OF AN ELECTRODE PAIR | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2008-08-14 | — | — | WO | disclosed |
| EP-1874738-A1 | PYRIMIDINES REACTING WITH O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE | Covalys Biosciences AG (CH) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006114409-A9 | PYRIMIDINES REACTING WITH O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE | COVALYS BIOSCIENCES AG (CH) | 2007-10-18 | — | — | WO | disclosed |
| WO-2006114409-A1 | PYRIMIDINES REACTING WITH O6-ALKYLGUANINE-DNA ALKYLTRANSFERASE | COVALYS BIOSCIENCES AG (CH) | 2006-11-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090186373-A1 | Pyrimidines reacting with O6-Alkylguanine-DNA alkyltransferase | HPRT1, UNG, DPYD | NUDT1 8/4885MAOB 787/4885ROCK1 4452/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.