Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.37 |
| ▸ | CTPS1 | P17812 | 1/20 | 0.36 |
| ▸ | GPR174 | Q9BXC1 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27485066 | 0.87 | SMN1; SMN2 (0.34) | MAPTALDH1A1MEN1KMT2AMAPK1 | |
| SCHEMBL27500661 | 0.87 | MAPT (0.43) | MAPTALDH1A1MAPK1SMN1; SMN2CYP1A2 | |
| SCHEMBL27485058 | 0.84 | SMN1; SMN2 (0.35) | MAPTALDH1A1KMT2AMAPK1SMN1; SMN2 | |
| SCHEMBL7139645 | 0.80 | MAPT (0.43) | MAPTALDH1A1MEN1KMT2ACSF1R | |
| SCHEMBL27486385 | 0.78 | ALDH1A1 (0.35) | MAPTALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL27500364 | 0.77 | ALDH1A1 (0.37) | MAPTALDH1A1MAPK1SMN1; SMN2TDP1 | |
| SCHEMBL27499444 | 0.76 | MAPT (0.42) | MAPTALDH1A1MEN1KMT2ACSF1R | |
| SCHEMBL27499149 | 0.76 | LMNA (0.38) | MAPTALDH1A1NPSR1POLBCYP1A2 | |
| SCHEMBL7141821 | 0.76 | MAPT (0.39) | MAPTALDH1A1MEN1KMT2ACSF1R | |
| SCHEMBL27498855 | 0.75 | MEN1 (0.34) | MAPTALDH1A1MEN1KMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1195522-C | Benzodiazepine derivatives usable as parental metabolic glutamate receptor antagonist | HOFFMANN LA ROCHE (CH) | 2005-04-06 | — | — | CN | disclosed |
| CN-1379765-A | Benzodiazepine derivatives usable as parental metabolic glutamate receptor antagonist | HOFFMANN LA ROCHE (CH) | 2002-11-13 | — | — | CN | disclosed |