Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 6/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | BCHE | P06276 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 1/20 | 0.31 |
| ▸ | CMA1 | P23946 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27500661 | 0.80 | MAPT (0.43) | ALDH1A1SMN1; SMN2MAPTLMNA | |
| SCHEMBL27485058 | 0.80 | SMN1; SMN2 (0.35) | ALDH1A1KMT2ASMN1; SMN2MAPTNPSR1 | |
| SCHEMBL7145848 | 0.79 | ALDH1A1 (0.36) | ALDH1A1KMT2ASMN1; SMN2MAPTNPSR1 | |
| SCHEMBL27499445 | 0.78 | MAPT (0.44) | ALDH1A1KMT2ASMN1; SMN2MAPTNPSR1 | |
| SCHEMBL27485066 | 0.78 | SMN1; SMN2 (0.34) | ALDH1A1KMT2ASMN1; SMN2MAPTNPSR1 | |
| SCHEMBL27486384 | 0.77 | CMA1 (0.35) | ALDH1A1KMT2ASMN1; SMN2MAPTPOLB | |
| SCHEMBL27500364 | 0.74 | ALDH1A1 (0.37) | ALDH1A1SMN1; SMN2MAPTNPSR1LMNA | |
| SCHEMBL27499149 | 0.73 | LMNA (0.38) | ALDH1A1MAPTNPSR1POLBLMNA | |
| SCHEMBL27498855 | 0.72 | MEN1 (0.34) | ALDH1A1KMT2AMAPTNPSR1MEN1 | |
| SCHEMBL27539426 | 0.72 | HCAR3 (0.37) | ALDH1A1KMT2ASMN1; SMN2MAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1195522-C | Benzodiazepine derivatives usable as parental metabolic glutamate receptor antagonist | HOFFMANN LA ROCHE (CH) | 2005-04-06 | — | — | CN | disclosed |
| CN-1379765-A | Benzodiazepine derivatives usable as parental metabolic glutamate receptor antagonist | HOFFMANN LA ROCHE (CH) | 2002-11-13 | — | — | CN | disclosed |