Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.45 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SLC13A5 | Q86YT5 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CPA1 | P15085 | 2/20 | 0.41 |
| ▸ | CPB1 | P15086 | 1/20 | 0.41 |
| ▸ | CPA3 | P15088 | 1/20 | 0.41 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.41 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL27471655 | 0.86 | AKR1B1 (0.65) | AKR1B1LMNAKDM4EMEN1CYP1A2 | |
| Citric Acid SCHEMBL6023385 | 0.83 | LMNA (0.51) | LMNAKDM4EMEN1CYP1A2CYP2D6 | |
| Citric Acid SCHEMBL290601 | 0.83 | ALDH1A1 (0.62) | LMNAKDM4ESMN1; SMN2ALDH1A1TSHR | |
| Citric Acid SCHEMBL28954897 | 0.81 | ALDH1A1 (0.60) | LMNAKDM4ESMN1; SMN2ALDH1A1TSHR | |
| Citric Acid SCHEMBL28954903 | 0.81 | ALDH1A1 (0.60) | LMNAKDM4ESMN1; SMN2ALDH1A1TSHR | |
| Citric Acid SCHEMBL3647975 | 0.81 | SMN1; SMN2 (0.60) | SMN1; SMN2ALDH1A1ACLY | |
| Citric Acid SCHEMBL3955190 | 0.81 | ALDH1A1 (0.60) | LMNAKDM4ESMN1; SMN2ALDH1A1TSHR | |
| Citric Acid SCHEMBL247921 | 0.81 | ALDH1A1 (0.60) | LMNAKDM4ESMN1; SMN2ALDH1A1TSHR | |
| Citric Acid SCHEMBL6662533 | 0.81 | ALDH1A1 (0.60) | LMNAKDM4ESMN1; SMN2ALDH1A1TSHR | |
| Citric Acid SCHEMBL28954908 | 0.81 | ALDH1A1 (0.60) | LMNAKDM4ESMN1; SMN2ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1183046-C | Method of purifying water, suitable bacteria for said method and use thereof | — | 2005-01-05 | — | — | CN | disclosed |
| CN-1420848-A | Water treatment method, microorganism suitable for the method and use thereof | CLEVO OY (FI) | 2003-05-28 | — | — | CN | disclosed |