Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 5/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | SLC13A5 | Q86YT5 | 3/20 | 0.40 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.37 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.37 |
| ▸ | CES2 | O00748 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | ACLY | P53396 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL8508556 | 0.91 | LMNA (0.62) | LMNAMAPK1ALDH1A1KDM4EMEN1 | |
| Citric Acid SCHEMBL10336054 | 0.87 | LMNA (0.56) | LMNAMAPK1ALDH1A1KDM4EMEN1 | |
| Mandelic Acid SCHEMBL3711577 | 0.86 | LMNA (0.69) | LMNAMAPK1SMN1; SMN2CYP2D6GABBR2 | |
| Citric Acid SCHEMBL27500656 | 0.83 | AKR1B1 (0.49) | LMNASMN1; SMN2ALDH1A1KDM4EMEN1 | |
| Citric Acid SCHEMBL290601 | 0.83 | ALDH1A1 (0.62) | LMNASMN1; SMN2ALDH1A1KDM4EMAPT | |
| Mandelic Acid SCHEMBL3456058 | 0.82 | LMNA (0.62) | LMNAMAPK1SMN1; SMN2CYP2D6MAPT | |
| Citric Acid SCHEMBL3647975 | 0.81 | SMN1; SMN2 (0.60) | SMN1; SMN2ALDH1A1ACLY | |
| Citric Acid SCHEMBL28954897 | 0.81 | ALDH1A1 (0.60) | LMNASMN1; SMN2ALDH1A1KDM4EMAPT | |
| Citric Acid SCHEMBL6662533 | 0.81 | ALDH1A1 (0.60) | LMNASMN1; SMN2ALDH1A1KDM4EMAPT | |
| Citric Acid SCHEMBL28954908 | 0.81 | ALDH1A1 (0.60) | LMNASMN1; SMN2ALDH1A1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0957080-B1 | NOVEL ETHYLAMINE DERIVATIVES | FUJIMOTO BROTHERS CO LTD (JP) | 2006-06-21 | — | — | EP | disclosed |