Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27486047 | 0.89 | HTT (0.43) | HTTSMN1; SMN2ALDH1A1MAPTLMNA | |
| SCHEMBL27484676 | 0.79 | MAPT (0.61) | HTTSMN1; SMN2ALDH1A1MAPTLMNA | |
| SCHEMBL12912355 | 0.79 | ALDH1A1 (0.56) | SMN1; SMN2ALDH1A1MAPTLMNANPC1 | |
| SCHEMBL5724018 | 0.77 | SMN1; SMN2 (0.51) | SMN1; SMN2ALDH1A1MAPTLMNANPC1 | |
| SCHEMBL13713047 | 0.77 | SMN1; SMN2 (0.54) | HTTSMN1; SMN2ALDH1A1MAPTLMNA | |
| SCHEMBL6401181 | 0.76 | SMN1; SMN2 (0.50) | SMN1; SMN2ALDH1A1MAPTLMNANPC1 | |
| SCHEMBL5724109 | 0.76 | SMN1; SMN2 (0.51) | SMN1; SMN2ALDH1A1MAPTLMNANPC1 | |
| SCHEMBL10639271 | 0.76 | SMN1; SMN2 (0.50) | HTTSMN1; SMN2ALDH1A1MAPTLMNA | |
| SCHEMBL17825504 | 0.76 | HTT (0.61) | HTTSMN1; SMN2NPC1RAB9AGRIN2B | |
| SCHEMBL27499710 | 0.76 | CYP1A2 (0.55) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1183770-A | Piperazine derivatives, medicaments containing these compounds, their use and processes for their preparation | THOMAE GMBH DR K (DE) | 1998-06-03 | — | — | CN | disclosed |