Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Tetrahydrofuran. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | UGT2B17 | O75795 | 2/20 | 0.32 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL27130370 | 0.81 | RAPGEF4 (0.43) | ALDH1A1MAPTPOLBUGT2B17RAPGEF4 | |
| Tetrahydrofuran SCHEMBL28161889 | 0.78 | ALDH1A1 (0.50) | ALDH1A1MAPTMAPK1POLB | |
| Bromide SCHEMBL28282967 | 0.76 | RAPGEF4 (0.39) | ALDH1A1MAPTPOLBUGT2B17RAPGEF4 | |
| Tetrahydrofuran SCHEMBL5596603 | 0.76 | ALDH1A1 (0.36) | ALDH1A1MAPTMAPK1POLBRAPGEF4 | |
| Hydrochloric Acid SCHEMBL27538451 | 0.75 | RAPGEF4 (0.43) | ALDH1A1MAPTPOLBUGT2B17RAPGEF4 | |
| Tetrahydrofuran SCHEMBL5613822 | 0.74 | ALDH1A1 (0.35) | ALDH1A1MAPTMAPK1POLBRAPGEF4 | |
| Tetrahydrofuran SCHEMBL5596334 | 0.74 | ALDH1A1 (0.35) | ALDH1A1MAPTMAPK1POLBRAPGEF4 | |
| Tetrahydrofuran SCHEMBL27929993 | 0.72 | ALDH1A1 (0.33) | ALDH1A1MAPTMAPK1POLBRAPGEF4 | |
| Tetrahydrofuran SCHEMBL28535994 | 0.70 | ALDH1A1 (0.40) | ALDH1A1MAPTMAPK1 | |
| Tetrahydrofuran SCHEMBL28811344 | 0.68 | ALDH1A1 (0.38) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1240691-C | Substituted five-membered nitrogen heterocyclic compound and application thereof in preventing and treating neurodegenerative diseases | TOXICANT AND MEDICINE INST MIL (CN) | 2006-02-08 | — | — | CN | disclosed |
| CN-1422851-A | Substituted five-membered nitrogen heterocyclic compound and application thereof in preventing and treating neurodegenerative diseases | TOXICANT AND MEDICINE INST MIL (CN) | 2003-06-11 | — | — | CN | disclosed |