Tetrahydrofuran

Tetrahydrofuran

SCHEMBL5596334

C1CCOC1.Cc1cc(C)c([Cr]c2c(C)cc(C)cc2C)c(C)c1

nearest known ligand 0.35

Full drug profile on Sugi Atlas →

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.35
MAPT P10636 2/20 0.34
MAPK1 P28482 1/20 0.34
POLB P06746 1/20 0.33
RAPGEF4 Q8WZA2 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL673082 0.81 RAPGEF4 (0.43) ALDH1A1MAPTPOLBRAPGEF4
Tetrahydrofuran SCHEMBL28161889 0.78 ALDH1A1 (0.50) ALDH1A1MAPTMAPK1POLB
Tetrahydrofuran SCHEMBL5596603 0.76 ALDH1A1 (0.36) ALDH1A1MAPTMAPK1POLBRAPGEF4
Tetrahydrofuran SCHEMBL5613822 0.74 ALDH1A1 (0.35) ALDH1A1MAPTMAPK1POLBRAPGEF4
Tetrahydrofuran SCHEMBL27503249 0.74 ALDH1A1 (0.35) ALDH1A1MAPTMAPK1POLBRAPGEF4
Tetrahydrofuran SCHEMBL27929993 0.72 ALDH1A1 (0.33) ALDH1A1MAPTMAPK1POLBRAPGEF4
Tetrahydrofuran SCHEMBL28535994 0.70 ALDH1A1 (0.40) ALDH1A1MAPTMAPK1
Tetrahydrofuran SCHEMBL28811344 0.68 ALDH1A1 (0.38) ALDH1A1
P-Xylene SCHEMBL21806075 0.68 ACHE (0.50) ALDH1A1
Dioxane SCHEMBL3458161 0.67 ALDH1A1 (0.44) ALDH1A1MAPTMAPK1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7279537-B2 Transition metal complexes and polymerization catalysts SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2007-10-09 US disclosed
US-20060229195-A1 Transition metal complexes and polymerization catalysts SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2006-10-12 US disclosed
EP-1557423-A1 TRANSITION METAL COMPLEXES AND POLYMERIZATION CATALYSTS Sumitomo Chemical Company, Limited (JP) 2005-07-27 EP disclosed