Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 2/20 | 0.46 |
| ▸ | CA9 | Q16790 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 5/20 | 0.45 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 3/20 | 0.44 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.44 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.44 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16187157 | 0.87 | CTDSP1 (0.45) | CYP3A4CTDSP1POLBGAATDP1 | |
| SCHEMBL27529724 | 0.87 | CYP3A4 (0.54) | CYP3A4LMNACA12CA9KDM4E | |
| SCHEMBL9610674 | 0.84 | ELANE (0.47) | CYP3A4CTDSP1MTNR1AMTNR1BHTR2C | |
| SCHEMBL7079680 | 0.84 | MTNR1A (0.48) | CTDSP1MTNR1AMTNR1BHTR2CHTR2B | |
| SCHEMBL29940384 | 0.83 | KDM4E (0.50) | CYP3A4LMNACA12CA9POLB | |
| SCHEMBL10458103 | 0.83 | LMNA (0.54) | CYP3A4LMNACA12CA9POLB | |
| SCHEMBL1143252 | 0.83 | KDM4E (0.50) | CYP3A4LMNACA12CA9POLB | |
| SCHEMBL27497870 | 0.83 | MAPT (0.50) | CYP3A4LMNACTDSP1CA12CA9 | |
| SCHEMBL29257065 | 0.82 | CYP3A4 (0.49) | CYP3A4LMNACA12CA9POLB | |
| SCHEMBL13888153 | 0.82 | MTNR1A (0.54) | MTNR1AMTNR1BHTR2CHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1256326-C | Novel 4- (oxoxyphenyl) -3-oxopiperidines for the treatment of cardiac and renal insufficiency | HOFFMANN LA ROCHE (CH) | 2006-05-17 | — | — | CN | disclosed |
| CN-1202152-A | Novel 4- (oxoxyphenyl) -3-oxopiperidines for the treatment of cardiac and renal insufficiency | HOFFMANN LA ROCHE (CH) | 1998-12-16 | — | — | CN | disclosed |