Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.46 |
| ▸ | HRH1 | P35367 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | GBA1 | P04062 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 2/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7520554 | 0.82 | — | — | |
| SCHEMBL4725232 | 0.82 | — | — | |
| SCHEMBL3044569 | 0.70 | GBA1 (0.56) | KMT2AGBA1KDM1AMAOB | |
| SCHEMBL5012792 | 0.70 | — | — | |
| SCHEMBL1099712 | 0.70 | — | — | |
| SCHEMBL1477350 | 0.69 | MAOA (0.49) | SLC6A2SLC6A4SLC6A3GBA1KDM1A | |
| SCHEMBL7972743 | 0.69 | ITGB3 (0.51) | HRH1KMT2AGBA1KDM1AMAOB | |
| SCHEMBL2916272 | 0.69 | SLC6A1 (0.33) | — | |
| SCHEMBL331464 | 0.69 | — | — | |
| Iodide SCHEMBL9406522 | 0.69 | SLC6A1 (0.41) | SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1168728-C | Pyrroloisoquinoline and tetrahydropyrroloisoquinoline derivatives and their use as 5-HT 7 receptor mediators | 惠氏公司 | 2004-09-29 | — | — | CN | disclosed |
| CN-1396921-A | Pyrroloisoquinoline and tetrahydropyrroloisoquinoline derivatives and their use as 5-HT 7 receptor mediators | WYETH CORP (US) | 2003-02-12 | — | — | CN | disclosed |