Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.36 |
| ▸ | NAAA | Q02083 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | CASP6 | P55212 | 1/20 | 0.34 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL732313 | 0.86 | SMN1; SMN2 (0.52) | SMN1; SMN2CYP1A2TDP1KDM4ENOTUM | |
| SCHEMBL29257696 | 0.83 | SMN1; SMN2 (0.48) | SMN1; SMN2CYP1A2TDP1KDM4ENOTUM | |
| SCHEMBL17094569 | 0.83 | SMN1; SMN2 (0.58) | SMN1; SMN2CYP1A2TDP1KDM4ENOTUM | |
| SCHEMBL5069192 | 0.75 | SMN1; SMN2 (0.41) | SMN1; SMN2CYP1A2TDP1KDM4ENOTUM | |
| SCHEMBL27961029 | 0.73 | LMNA (0.35) | NAAAALDH1A1 | |
| SCHEMBL4236 | 0.72 | — | — | |
| SCHEMBL2187341 | 0.72 | — | — | |
| SCHEMBL13921120 | 0.70 | SMN1; SMN2 (1.00) | SMN1; SMN2CYP1A2TDP1KDM4EKMT2A | |
| SCHEMBL13173709 | 0.70 | SMN1; SMN2 (1.00) | SMN1; SMN2CYP1A2TDP1KDM4EKMT2A | |
| Hydrochloric Acid SCHEMBL5485891 | 0.70 | SMN1; SMN2 (0.90) | SMN1; SMN2CYP1A2TDP1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102007118-B | Pyrrolidinone glucokinase activators | HOFFMANN LA ROCHE | 2014-12-31 | — | — | CN | disclosed |
| CN-102007118-A | Pyrrolidinone glucokinase activators | HOFFMANN LA ROCHE | 2011-04-06 | — | — | CN | disclosed |
| CN-101077875-B | Boronic ester and acid compounds, synthesis and uses | MILLENNIUM PHARM INC | 2011-01-26 | — | — | CN | disclosed |
| CN-101077875-A | Boronic ester and acid compounds, synthesis and uses | MILLENNIUM PHARM INC (US) | 2007-11-28 | — | — | CN | disclosed |
| CN-1305475-C | Boronic ester and acid compounds, their synthesis and use | PROSCRIPT INC (US) | 2007-03-21 | — | — | CN | disclosed |
| CN-1168633-A | Boronic ester and acid compounds, their synthesis and use | PROSCRIPT INC (US) | 1997-12-24 | — | — | CN | disclosed |