Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.34 |
| ▸ | PTAFR | P25105 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | ERN1 | O75460 | 1/20 | 0.30 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | GFER | P55789 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL732313 | 0.87 | SMN1; SMN2 (0.52) | SMN1; SMN2NOTUMPTAFRCYP1A2TDP1 | |
| SCHEMBL756510 | 0.83 | ALDH1A1 (0.42) | ALDH1A1LMNATSHR | |
| SCHEMBL27508694 | 0.75 | SMN1; SMN2 (0.54) | SMN1; SMN2NOTUMCYP1A2TDP1ALDH1A1 | |
| SCHEMBL17094569 | 0.74 | SMN1; SMN2 (0.58) | SMN1; SMN2NOTUMPTAFRCYP1A2TDP1 | |
| SCHEMBL29257696 | 0.71 | SMN1; SMN2 (0.48) | SMN1; SMN2NOTUMCYP1A2TDP1LMNA | |
| SCHEMBL1307070 | 0.70 | CYP1A2 (0.54) | SMN1; SMN2CYP1A2TDP1ALDH1A1HPGD | |
| SCHEMBL28112414 | 0.67 | — | — | |
| SCHEMBL20055706 | 0.67 | CYP1A2 (0.44) | SMN1; SMN2CYP1A2TDP1MEN1ALDH1A1 | |
| SCHEMBL19813205 | 0.66 | USP2 (0.60) | SMN1; SMN2MEN1ALDH1A1LMNAMAPT | |
| SCHEMBL12192691 | 0.65 | CYP1A2 (0.48) | SMN1; SMN2CYP1A2TDP1MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1984036-A2 | 4-AZA-CAPROLACTONE-BASED POLYMERIC COMPOSITIONS USEFUL FOR THE MANUFACTURE OF BIODEGRADABLE MEDICAL DEVICES AND AS MEDICAL DEVICE COATINGS | Medtronic Vascular Inc. (US) | 2008-10-29 | — | — | EP | disclosed |
| WO-2007024481-A2 | 4-AZA-CAPROLACTONE-BASED POLYMERIC COMPOSITIONS USEFUL FOR THE MANUFACTURE OF BIODEGRADABLE MEDICAL DEVICES AND AS MEDICAL DEVICE COATINGS | MEDTRONIC VASCULAR, INC. (US) | 2007-03-01 | — | — | WO | disclosed |