Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | PTAFR | P25105 | 1/20 | 0.37 |
| ▸ | CASP6 | P55212 | 1/20 | 0.33 |
| ▸ | GFER | P55789 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5069192 | 0.87 | SMN1; SMN2 (0.41) | SMN1; SMN2CYP1A2TDP1ALDH1A1LMNA | |
| SCHEMBL27508694 | 0.86 | SMN1; SMN2 (0.54) | SMN1; SMN2CYP1A2TDP1ALDH1A1NOTUM | |
| SCHEMBL17094569 | 0.85 | SMN1; SMN2 (0.58) | SMN1; SMN2CYP1A2TDP1ALDH1A1NOTUM | |
| SCHEMBL29257696 | 0.82 | SMN1; SMN2 (0.48) | SMN1; SMN2CYP1A2TDP1LMNANOTUM | |
| SCHEMBL19813205 | 0.75 | USP2 (0.60) | SMN1; SMN2ALDH1A1LMNAKDM4EHPGD | |
| SCHEMBL137219 | 0.73 | CYP1A2 (0.50) | SMN1; SMN2CYP1A2TDP1ALDH1A1NOTUM | |
| SCHEMBL11070126 | 0.73 | CYP1A2 (0.50) | SMN1; SMN2CYP1A2TDP1ALDH1A1TSHR | |
| SCHEMBL4236 | 0.71 | — | — | |
| SCHEMBL2187341 | 0.71 | — | — | |
| SCHEMBL19813213 | 0.71 | KMT2A (0.43) | SMN1; SMN2ALDH1A1LMNATSHRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8273828-B2 | Methods for introducing reactive secondary amines pendant to polymers backbones that are useful for diazeniumdiolation | MEDTRONIC VASCULAR, INC. (US) | 2012-09-25 | — | — | US | claimed |
| JP-2010534270-A | — | — | 2010-11-04 | — | — | JP | claimed |
| EP-2185603-A2 | METHODS FOR INTRODUCTING REACTIVE SECONDARY AMINES PENDANT TO POLYMER BACKBONES THAT ARE USEFUL FOR DIAZENIUMDIOLATION | Medtronic Vascular Inc. (US) | 2010-05-19 | — | — | EP | claimed |
| US-20090028966-A1 | Methods for Introducing Reactive Secondary Amines Pendant to Polymers Backbones that are Useful for Diazeniumdiolation | MEDTRONIC VASCULAR, INC. (US) | 2009-01-29 | — | — | US | claimed |
| WO-2009014829-A2 | METHODS FOR INTRODUCING REACTIVE SECONDARY AMINES PENDANT TO POLYMER BACKBONES THAT ARE USEFUL FOR DIAZENIUMDIOLATION | MEDTRONIC VASCULAR INC. (US) | 2009-01-29 | — | — | WO | claimed |
| US-8968763-B2 | Block biodegradable copolymers for medical devices | MEDTRONIC VASCULAR, INC. (US) | 2015-03-03 | — | — | US | disclosed |
| US-8968763-B2 | Block biodegradable copolymers for medical devices | MEDTRONIC VASCULAR, INC. (US) | 2015-03-03 | — | — | US | disclosed |
| US-8273828-B2 | Methods for introducing reactive secondary amines pendant to polymers backbones that are useful for diazeniumdiolation | MEDTRONIC VASCULAR, INC. (US) | 2012-09-25 | — | — | US | disclosed |
| US-8273828-B2 | Methods for introducing reactive secondary amines pendant to polymers backbones that are useful for diazeniumdiolation | MEDTRONIC VASCULAR, INC. (US) | 2012-09-25 | — | — | US | disclosed |
| US-8273828-B2 | Methods for introducing reactive secondary amines pendant to polymers backbones that are useful for diazeniumdiolation | MEDTRONIC VASCULAR, INC. (US) | 2012-09-25 | — | — | US | disclosed |
| US-8137687-B2 | Implantable medical device having a coating of a biocompatible polylactone from N-substituted 4-aza-caprolactone | MEDTRONIC VASCULAR, INC. (US) | 2012-03-20 | — | — | US | disclosed |
| US-8137687-B2 | Implantable medical device having a coating of a biocompatible polylactone from N-substituted 4-aza-caprolactone | MEDTRONIC VASCULAR, INC. (US) | 2012-03-20 | — | — | US | disclosed |
| WO-2007133924-A2 | BIODEGRADABLE MODIFIED CAPROLACTONE POLYMERS FOR FABRICATING AND COATING MEDICAL DEVICES | MEDTRONIC VASCULAR, INC. (US) | 2007-11-22 | — | — | WO | disclosed |
| US-20070264307-A1 | Biodegradable Modified Caprolactone Polymers for Fabricating and Coating Medical Devices | MEDTRONIC VASCULAR, INC. (US) | 2007-11-15 | — | — | US | disclosed |
| US-20070264307-A1 | Biodegradable Modified Caprolactone Polymers for Fabricating and Coating Medical Devices | MEDTRONIC VASCULAR, INC. (US) | 2007-11-15 | — | — | US | disclosed |
| WO-2007121055-A1 | BIODEGRADABLE BIOCOMPATIBLE AMPHIPHILIC COPOLYMERS FOR COATING AND MANUFACTURING MEDICAL DEVICES | MEDTRONIC VASCULAR, INC. (US) | 2007-10-25 | — | — | WO | disclosed |
| US-20070237803-A1 | Biodegradable Biocompatible Amphiphilic Copolymers for Coating and Manufacturing Medical Devices | MEDTRONIC VASCULAR, INC. (US) | 2007-10-11 | — | — | US | disclosed |
| US-20070237803-A1 | Biodegradable Biocompatible Amphiphilic Copolymers for Coating and Manufacturing Medical Devices | MEDTRONIC VASCULAR, INC. (US) | 2007-10-11 | — | — | US | disclosed |
| WO-2007024481-A2 | 4-AZA-CAPROLACTONE-BASED POLYMERIC COMPOSITIONS USEFUL FOR THE MANUFACTURE OF BIODEGRADABLE MEDICAL DEVICES AND AS MEDICAL DEVICE COATINGS | MEDTRONIC VASCULAR, INC. (US) | 2007-03-01 | — | — | WO | disclosed |
| WO-2007024481-A2 | 4-AZA-CAPROLACTONE-BASED POLYMERIC COMPOSITIONS USEFUL FOR THE MANUFACTURE OF BIODEGRADABLE MEDICAL DEVICES AND AS MEDICAL DEVICE COATINGS | MEDTRONIC VASCULAR, INC. (US) | 2007-03-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090028966-A1 | Methods for Introducing Reactive Secondary Amines Pendant to Polymers Backbones that are Useful for Diazeniumdiolation | NOS2, NOS1, NOS3 | SMN1; SMN2 2473/4885CYP1A2 552/4885TDP1 484/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.