Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.34 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
| ▸ | CYP24A1 | Q07973 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.33 |
| ▸ | STAT3 | P40763 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | CA9 | Q16790 | 2/20 | 0.33 |
| ▸ | MMP13 | P45452 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27473991 | 1.00 | ALDH1A1 (0.39) | ALDH1A1KMT2AMEN1HTTSMN1; SMN2 | |
| SCHEMBL27473170 | 1.00 | ALDH1A1 (0.39) | ALDH1A1KMT2AMEN1HTTSMN1; SMN2 | |
| SCHEMBL27988722 | 0.84 | ALDH1A1 (0.37) | ALDH1A1KMT2AMEN1HTTSMN1; SMN2 | |
| SCHEMBL27710803 | 0.82 | STAT3 (0.39) | ALDH1A1KMT2AMEN1SMN1; SMN2LMNA | |
| SCHEMBL7412821 | 0.78 | KMT2A (0.41) | ALDH1A1KMT2AMEN1HTTSMN1; SMN2 | |
| SCHEMBL7366077 | 0.78 | KMT2A (0.41) | ALDH1A1KMT2AMEN1HTTSMN1; SMN2 | |
| SCHEMBL10465481 | 0.78 | KDM4E (0.48) | ALDH1A1KMT2AMEN1SMN1; SMN2LMNA | |
| SCHEMBL8557368 | 0.78 | KDM4E (0.48) | ALDH1A1KMT2AMEN1SMN1; SMN2LMNA | |
| SCHEMBL21046004 | 0.77 | CA2 (0.43) | ALDH1A1KMT2AMEN1HTTLMNA | |
| SCHEMBL16935947 | 0.77 | CA2 (0.43) | ALDH1A1KMT2AMEN1HTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104341388-A | Aromatic amide derivative as well as preparation method and medicinal application thereof | SHANGHAI RUNNUO BIOTECHNOLOGY CO LTD | 2015-02-11 | — | — | CN | disclosed |
| CN-1178911-C | pyrrolidine and piperidine derivatives and their use for the treatment of neurodegenerative diseases | - | 2004-12-08 | — | — | CN | disclosed |
| CN-1425002-A | Pyrrolidine and piperidine derivatives and their use for treatment of neurodegenerative disorders | HOFFMANN LA ROCHE (CH) | 2003-06-18 | — | — | CN | disclosed |