Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Uracil. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 1/20 | 0.68 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.31 |
| ▸ | TYMP | P19971 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Uracil SCHEMBL27495406 | 1.00 | CRBN (0.68) | CRBNMMP2TP53CA1CYP1A2 | |
| Uracil SCHEMBL2895224 | 1.00 | CRBN (0.68) | CRBNMMP2TP53CA1CYP1A2 | |
| Uracil SCHEMBL479740 | 0.88 | CRBN (0.74) | CRBNMMP2TP53CA1CYP1A2 | |
| Uracil SCHEMBL2895220 | 0.86 | CRBN (0.71) | CRBNMMP2TP53CA1CYP1A2 | |
| Uracil SCHEMBL3798527 | 0.82 | CRBN (1.00) | CRBNMMP2TP53CA1ALDH1A1 | |
| Uracil SCHEMBL8235 | 0.82 | — | — | |
| Uracil SCHEMBL5089507 | 0.82 | — | — | |
| Uracil SCHEMBL9429688 | 0.81 | CRBN (0.77) | CRBNMMP2TP53CYP1A2ALDH1A1 | |
| Uracil SCHEMBL25208560 | 0.81 | CRBN (0.63) | CRBNMMP2TP53CYP1A2ALDH1A1 | |
| Uracil SCHEMBL4664232 | 0.80 | CRBN (0.94) | CRBNMMP2TP53CA1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1223637-C | perfume ink-jet ink | BENQ CORP (CN) | 2005-10-19 | — | — | CN | claimed |
| CN-1393491-A | perfume ink-jet ink | BENQ CORP (CN) | 2003-01-29 | — | — | CN | claimed |
| CN-1223637-C | perfume ink-jet ink | BENQ CORP (CN) | 2005-10-19 | — | — | CN | disclosed |
| CN-1393491-A | perfume ink-jet ink | BENQ CORP (CN) | 2003-01-29 | — | — | CN | disclosed |