Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | MGAM | O43451 | 1/20 | 0.50 |
| ▸ | SI | P14410 | 1/20 | 0.50 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.46 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8677 | 0.98 | — | — | |
| Ammonia Solution, Strong SCHEMBL3775021 | 0.95 | GAA (0.50) | GAAMGAMSIMGAM2ALDH1A1 | |
| Methylene Chloride SCHEMBL3731960 | 0.93 | GAA (0.48) | GAAMGAMSIMGAM2ALDH1A1 | |
| Alcohol SCHEMBL4242917 | 0.93 | GAA (0.48) | GAAMGAMSIMGAM2ALDH1A1 | |
| Acetone SCHEMBL7006638 | 0.93 | GAA (0.48) | GAAMGAMSIMGAM2ALDH1A1 | |
| Ether SCHEMBL826068 | 0.91 | GAA (0.46) | GAAMGAMSIMGAM2ALDH1A1 | |
| Acetic Acid SCHEMBL5092211 | 0.91 | GAA (0.46) | GAAMGAMSIMGAM2ALDH1A1 | |
| Ethyl Acetate SCHEMBL8741598 | 0.89 | ALDH1A1 (0.58) | GAAMGAMSIMGAM2ALDH1A1 | |
| Ethyl Acetate SCHEMBL2089133 | 0.89 | ALDH1A1 (0.58) | GAAMGAMSIMGAM2ALDH1A1 | |
| Ethyl Acetate SCHEMBL5800063 | 0.89 | ALDH1A1 (0.58) | GAAMGAMSIMGAM2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 149 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024001967-A1 | IMIDAZONAPHTHYRIDINE COMPOUND WITH AFFINITY WITH TAU PROTEIN, METHOD FOR PREPARING SAME, AND USE THEREOF | 北京师范大学 | 2024-01-04 | — | — | WO | disclosed |
| US-10202345-B2 | Substituted azaspiro(4.5)decane derivatives | GRUENENTHAL GMBH (DE) | 2019-02-12 | — | — | US | disclosed |
| US-20170210734-A1 | Substituted Azaspiro(4.5)Decane Derivatives | GRUENENTHAL GMBH (DE) | 2017-07-27 | — | — | US | disclosed |
| US-20160016903-A1 | Substituted Azaspiro(4.5)Decane Derivatives | GRUENENTHAL GMBH (DE) | 2016-01-21 | — | — | US | disclosed |
| US-8765766-B2 | Pyrimidine derivatives which are antagonists of the vitronectin receptor | GALAPAGOS NV (BE) | 2014-07-01 | — | — | US | disclosed |
| US-8492560-B2 | Quinazoline derivatives as angiogenesis inhibitors | ASTRAZENECA AB (SE) | 2013-07-23 | — | — | US | disclosed |
| US-20120197027-A1 | Quinazoline Derivatives as Angiogenesis Inhibitors | STOKES ELAINE S E (GB) | 2012-08-02 | — | — | US | disclosed |
| US-8188102-B2 | Amide derivative for inhibiting the growth of cancer cells | HANMI HOLDINGS CO., LTD. (KR) | 2012-05-29 | — | — | US | disclosed |
| US-20120115883-A1 | PYRIMIDINE DERIVATIVES WHICH ARE ANTAGONISTS OF THE VITRONECTIN RECEPTOR | GALAPAGOS SAS | 2012-05-10 | — | — | US | disclosed |
| US-8133896-B2 | Pyrimidine derivatives which are antagonist of the vitronectin receptor | GALAPAGOS NV (BE) | 2012-03-13 | — | — | US | disclosed |
| US-4347365-A | ANTICONVULSANTS, MUSCLE RELAXANTS, SEDATIVES | HOFFMANN-LA ROCHE INC. (US) | 1982-08-31 | — | — | US | disclosed |
| US-4322423-A | 4-Phenyl-4,5,6,7-tetrahydro-thieno(2,3-C)pyridines and salts thereof | BOEHRINGER INGELHEIM GMBH (DE) | 1982-03-30 | — | — | US | disclosed |
| US-4307237-A | ANTICONVULSANTS, SEDATIVES, MUSCLE RELAXANTS | HOFFMANN-LA ROCHE INC. (US) | 1981-12-22 | — | — | US | disclosed |
| US-4280957-A | Imidazodiazepines and processes therefor | HOFFMANN-LA ROCHE INC. (US) | 1981-07-28 | — | — | US | disclosed |
| EP-0014053-A1 | Synthesis of vindesine; vincaleukoblastine compounds | ELI LILLY AND COMPANY (US) | 1980-08-06 | — | — | EP | disclosed |
| US-4210584-A | Vindesine synthesis | ELI LILLY AND COMPANY (US) | 1980-07-01 | — | — | US | disclosed |
| US-4189537-A | Process of producing antibiotic BL580Δ with Streptomyces hygroscopicus | AMERICAN CYANAMID COMPANY (US) | 1980-02-19 | — | — | US | disclosed |
| US-4138481-A | ANTICOCCIDIAL AGENTS | AMERICAN CYANAMID COMPANY (US) | 1979-02-06 | — | — | US | disclosed |
| US-4132779-A | Antibiotic BL580 Zeta and use thereof as anticoccidial agent | AMERICAN CYANAMID COMPANY (US) | 1979-01-02 | — | — | US | disclosed |
| US-4115388-A | ANTI-TUMOR AGENTS | ELI LILLY AND COMPANY (US) | 1978-09-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10202345-B2 | Substituted azaspiro(4.5)decane derivatives | OPRL1, OPRD1, OPRM1 | GAA 4184/4885MGAM 4416/4885SI 4325/4885 |
| US-20120197027-A1 | Quinazoline Derivatives as Angiogenesis Inhibitors | VEGFA, FLT1, KDR | GAA 2479/4885MGAM 3529/4885SI 489/4885 |
| US-20170210734-A1 | Substituted Azaspiro(4.5)Decane Derivatives | OPRL1, OPRM1, OPRD1 | GAA 4141/4885MGAM 4431/4885SI 4262/4885 |
| US-20160016903-A1 | Substituted Azaspiro(4.5)Decane Derivatives | OPRL1, OPRD1, OPRM1 | GAA 4184/4885MGAM 4416/4885SI 4325/4885 |
| US-20120115883-A1 | PYRIMIDINE DERIVATIVES WHICH ARE ANTAGONISTS OF THE VITRONECTIN RECEPTOR | P2RY1, P2RY2, P2RX5 | GAA 4383/4885MGAM 4459/4885SI 3309/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.