Known targets — ChEMBL curated mechanism
KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2
The experimentally established mechanism targets of Dalfampridine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA1 known ✓ | Q09470 | 1/20 | 0.68 |
| ▸ | MAPT | P10636 | 6/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.68 |
| ▸ | MEN1 | O00255 | 3/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.68 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.68 |
| ▸ | LMNA | P02545 | 2/20 | 0.68 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.68 |
| ▸ | TSHR | P16473 | 1/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.68 |
| ▸ | RAD52 | P43351 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.40 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dalfampridine SCHEMBL28027907 | 0.89 | MAPT (0.77) | MAPTALDH1A1MEN1KMT2ACYP2D6 | |
| Dalfampridine SCHEMBL53483 | 0.83 | — | — | |
| Dalfampridine SCHEMBL1442620 | 0.83 | MAPT (1.00) | MAPTALDH1A1MEN1KMT2ACYP2D6 | |
| Dalfampridine SCHEMBL27592753 | 0.81 | MAPT (0.72) | MAPTALDH1A1MEN1KMT2ACYP2D6 | |
| Dalfampridine SCHEMBL28737546 | 0.80 | — | — | |
| Dalfampridine SCHEMBL7987482 | 0.80 | — | — | |
| Dalfampridine SCHEMBL7113651 | 0.80 | — | — | |
| Dalfampridine SCHEMBL28629661 | 0.80 | — | — | |
| Dalfampridine SCHEMBL28750367 | 0.80 | MAPT (0.93) | MAPTALDH1A1MEN1KMT2ACYP2D6 | |
| Dalfampridine SCHEMBL3845825 | 0.80 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105072897-B | Temperature stabilization cloquitocet_mexyl Aquo-composition | 美国陶氏益农公司 | 2017-04-05 | — | — | CN | claimed |
| CN-105072897-A | Temperature stable cloquintocet-mexyl aqueous compositions | DOW AGROSCIENCES LLC | 2015-11-18 | — | — | CN | claimed |
| CN-104994734-A | SYNERGISTIC WEED CONTROL FROM APPLICATIONS OF AMINOPYRALID AND CLOPYRALID | DOW AGROSCIENCES LLC | 2015-10-21 | — | — | CN | claimed |
| CN-102605356-B | Plating catalyst and method | ROHM & HAAS ELECT MAT | 2014-11-19 | — | — | CN | claimed |
| CN-1281591-C | 4-aminopyridinecarboxylates and their use as herbicides | DOW AGROSCIENCES LLC (US) | 2006-10-25 | — | — | CN | claimed |
| CN-110461819-A | Process for the preparation of benzyl 4-amino-3-chloro-5-fluoro-6- (4-chloro-2-fluoro-3-methoxyphenyl) picolinate | DOW AGROSCIENCES LLC | 2019-11-15 | — | — | CN | disclosed |
| CN-106279012-B | A kind of preparation method of 3,4,6- trichloropyridine -2- formic acid and its ester | 利尔化学股份有限公司 | 2019-04-09 | — | — | CN | disclosed |
| CN-106459060-B | Condensed triazole derivative as phosphodiesterase 10 A inhibitor | 赛隆制药股份公司 | 2019-04-05 | — | — | CN | disclosed |
| CN-104994734-B | Collaboration control of weeds is carried out by application chloroaminopyridine acid and clopyralid | 美国陶氏益农公司 | 2018-06-29 | — | — | CN | disclosed |
| CN-108135157-A | Complexes of cloquintocet-mexyl and amine-containing polymers or oligomers | 美国陶氏益农公司 | 2018-06-08 | — | — | CN | disclosed |
| CN-104994735-B | Using the collaboration control of weeds caused by the pyrimidine acid of ring third and 2,4 dichlorophenoxyacetic acids (2,4 drop) | 美国陶氏益农公司 | 2017-12-12 | — | — | CN | disclosed |
| CN-104988531-B | The method that a kind of selective dechlorination of chloro-pyridine formic acid electro-catalysis prepares pyridine carboxylic acid | 浙江工业大学 | 2017-11-07 | — | — | CN | disclosed |
| CN-1823045-A | 6-(1,1-difluoroalkyl)-4-aminopicolinates and their use as herbicides | DOW AGROSCIENCES LLC (US) | 2006-08-23 | — | — | CN | disclosed |
| CN-1764646-A | 6-alkyl-or alkenyl-4-aminopicolinates and their use as herbicides | DOW AGROSCIENCES LLC (US) | 2006-04-26 | — | — | CN | disclosed |
| CN-1751042-A | Pyrazolo[3,4-b]pyridine compounds, and their use as phosphodiesterase inhibitors | GLAXO GROUP LTD (GB) | 2006-03-22 | — | — | CN | disclosed |
| CN-1245401-C | 6-aryl-4-aminopicolinates and their use as herbicides | DOW AGROSCIENCES LLC (US) | 2006-03-15 | — | — | CN | disclosed |
| CN-1238565-C | Selective electrochemical reduction of halogenated 4-aminopicolinic acids | DOW AGROSCIENCES LLC (US) | 2006-01-25 | — | — | CN | disclosed |
| CN-1551876-A | 6-aryl-4-aminopicolinates and their use as herbicides | �ݶ�ũ������˾ | 2004-12-01 | — | — | CN | disclosed |
| CN-1416419-A | 4-aminopyridinecarboxylates and their use as herbicides | DOW AGROSCIENCES LLC (US) | 2003-05-07 | — | — | CN | disclosed |
| CN-1394241-A | Selective electrochemical reduction of halogenated 4-aminopicolinic acids | DOW AGROSCIENCES LLC (US) | 2003-01-29 | — | — | CN | disclosed |