Known targets — ChEMBL curated mechanism
KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2
The experimentally established mechanism targets of Dalfampridine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA1 known ✓ | Q09470 | 1/20 | 0.77 |
| ▸ | MAPT | P10636 | 5/20 | 0.77 |
| ▸ | MEN1 | O00255 | 3/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.77 |
| ▸ | LMNA | P02545 | 2/20 | 0.77 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.77 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.77 |
| ▸ | TSHR | P16473 | 1/20 | 0.77 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.77 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.77 |
| ▸ | RAD52 | P43351 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dalfampridine SCHEMBL27520243 | 0.89 | MAPT (0.68) | MAPTMEN1KMT2ALMNACYP2D6 | |
| Dalfampridine SCHEMBL1442620 | 0.87 | MAPT (1.00) | MAPTMEN1KMT2ALMNACYP2D6 | |
| Dalfampridine SCHEMBL53483 | 0.87 | — | — | |
| Dalfampridine SCHEMBL7987482 | 0.84 | — | — | |
| Dalfampridine SCHEMBL28750367 | 0.84 | MAPT (0.93) | MAPTMEN1KMT2ALMNACYP2D6 | |
| Dalfampridine SCHEMBL3845825 | 0.84 | — | — | |
| Dalfampridine SCHEMBL28799379 | 0.84 | — | — | |
| Dalfampridine SCHEMBL8968143 | 0.84 | — | — | |
| Dalfampridine SCHEMBL28976215 | 0.84 | — | — | |
| Dalfampridine SCHEMBL7113651 | 0.84 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105080513-B | A kind of chelate fibre, its synthetic method and the method that Cr VI is enriched with from serpentine | 浙江工商大学 | 2018-02-27 | — | — | CN | disclosed |
| CN-105174351-B | Prevent and treat the method for pollution of chromium and chelate fibre used in blackish green glass production | 浙江工商大学 | 2017-11-24 | — | — | CN | disclosed |
| CN-103597381-B | Color filter, CCD sensor, CMOS sensor, organic CMOS sensor, and solid-state image sensor | 富士胶片株式会社 | 2016-07-20 | — | — | CN | disclosed |
| CN-104018346-B | Cr (VI) is had to the synthetic method of the chelate fibre of selective absorption | ZHEJIANG GONGSHANG UNIVERSITY (CN) | 2016-01-27 | — | — | CN | disclosed |
| CN-105174351-A | Method of preventing and controlling chromium pollution in dark green glass production and used chelate fiber | UNIV ZHEJIANG GONGSHANG | 2015-12-23 | — | — | CN | disclosed |
| CN-105080513-A | Chelate fiber, synthetic method thereof and method for enriching hexavalent chromium from serpentine | UNIV ZHEJIANG GONGSHANG | 2015-11-25 | — | — | CN | disclosed |
| CN-104018346-A | Synthetic method of chelating fiber with selective adsorption on Cr (VI) | UNIV ZHEJIANG GONGSHANG | 2014-09-03 | — | — | CN | disclosed |