Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.71 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.69 |
| ▸ | MEN1 | O00255 | 2/20 | 0.69 |
| ▸ | HTT | P42858 | 1/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.68 |
| ▸ | LMNA | P02545 | 3/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.68 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.68 |
| ▸ | POLB | P06746 | 2/20 | 0.68 |
| ▸ | MAPT | P10636 | 2/20 | 0.63 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20365400 | 0.99 | KMT2A (0.72) | TAS1R3TAS1R1KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL2751300 | 0.85 | ALDH1A1 (0.70) | KMT2ASMN1; SMN2MEN1HTTKDM4E | |
| SCHEMBL8067567 | 0.84 | LMNA (0.57) | TAS1R3TAS1R1KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL8067570 | 0.84 | LMNA (0.57) | TAS1R3TAS1R1KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL701072 | 0.83 | TAS1R3 (1.00) | TAS1R3TAS1R1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL6439308 | 0.82 | KMT2A (1.00) | KMT2ASMN1; SMN2MEN1HTTKDM4E | |
| SCHEMBL21230470 | 0.82 | EPHX1 (0.67) | KMT2ASMN1; SMN2MEN1HTTKDM4E | |
| SCHEMBL10541879 | 0.82 | SMN1; SMN2 (0.62) | TAS1R3TAS1R1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL21230467 | 0.82 | TAS1R3 (0.71) | TAS1R3TAS1R1KMT2AMEN1KDM4E | |
| SCHEMBL2752803 | 0.82 | KMT2A (0.73) | KMT2AMEN1KDM4ELMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8178570-B2 | Tie-2 modulators and methods of use | EXELIXIS, INC. (US) | 2012-05-15 | — | — | US | disclosed |
| US-20060293342-A1 | Tie-2 modulators and methods of use | EXELIXIS, INC. (US) | 2006-12-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060293342-A1 | Tie-2 modulators and methods of use | TIE1, TEK, KDR | TAS1R3 3093/4885TAS1R1 3095/4885KMT2A 682/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.