Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.63 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.47 |
| ▸ | TGFBR1 | P36897 | 10/20 | 0.46 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.46 |
| ▸ | SMAD2 | Q15796 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.44 |
| ▸ | PFKFB3 | Q16875 | 3/20 | 0.43 |
| ▸ | VRK1 | Q99986 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16573976 | 0.87 | DYRK1A (0.60) | DYRK1AFFAR1TGFBR1BMPR1ASMAD2 | |
| SCHEMBL31214345 | 0.87 | DYRK1A (0.72) | DYRK1AFFAR1TGFBR1BMPR1ASMAD2 | |
| SCHEMBL27534916 | 0.86 | FFAR1 (0.47) | DYRK1AFFAR1TGFBR1RIPK1ALDH1A1 | |
| SCHEMBL22130152 | 0.80 | DYRK1A (0.70) | DYRK1AFFAR1TGFBR1BMPR1ASMAD2 | |
| SCHEMBL21780694 | 0.79 | DYRK1A (0.51) | DYRK1ATGFBR1BMPR1ASMAD2KDM4E | |
| SCHEMBL29870814 | 0.79 | RAB9A (0.54) | DYRK1ATGFBR1BMPR1ASMAD2KDM4E | |
| SCHEMBL266440 | 0.79 | RAB9A (0.54) | DYRK1ATGFBR1BMPR1ASMAD2KDM4E | |
| SCHEMBL6032917 | 0.78 | DYRK1A (0.62) | DYRK1AFFAR1TGFBR1BMPR1ASMAD2 | |
| SCHEMBL24155396 | 0.76 | DYRK1A (0.60) | DYRK1AFFAR1TGFBR1BMPR1ASMAD2 | |
| SCHEMBL6658073 | 0.76 | DYRK1A (0.60) | DYRK1AFFAR1TGFBR1BMPR1ASMAD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1290165-A | Benzothiazole Protein tyrosine kinase inhibitors | BRISTOL MYERS SQUIBB CO (US) | 2001-04-04 | — | — | CN | claimed |
| CN-1290165-A | Benzothiazole Protein tyrosine kinase inhibitors | BRISTOL MYERS SQUIBB CO (US) | 2001-04-04 | — | — | CN | disclosed |