Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | APEX1 | P27695 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL671829 | 0.91 | THRB (0.47) | THRBTSHRALDH1A1POLBAPEX1 | |
| SCHEMBL27590104 | 0.90 | THRB (0.39) | THRBTSHRALDH1A1POLBAPEX1 | |
| Sulfuric Acid SCHEMBL27971333 | 0.90 | THRB (0.41) | THRBTSHRALDH1A1POLBAPEX1 | |
| Hydrochloric Acid SCHEMBL555449 | 0.89 | THRB (0.50) | THRBTSHRALDH1A1POLBAPEX1 | |
| Sulfuric Acid Dimethyl Ester SCHEMBL27649716 | 0.87 | THRB (0.39) | THRBTSHRALDH1A1POLBAPEX1 | |
| SCHEMBL3899513 | 0.85 | THRB (0.38) | THRBTSHRALDH1A1POLB | |
| SCHEMBL16558569 | 0.81 | TSHR (0.40) | THRBTSHRALDH1A1 | |
| SCHEMBL11353726 | 0.78 | LMNA (0.47) | TSHRALDH1A1HTT | |
| Sulfuric Acid SCHEMBL11784028 | 0.78 | THRB (0.47) | THRBTSHRALDH1A1POLBAPEX1 | |
| SCHEMBL18183740 | 0.77 | TSHR (0.47) | THRBTSHRALDH1A1POLBAPEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1263445-C | Oxidation composition containing specific aminosiloxane for treating keratin fibers | OREAL (FR) | 2006-07-12 | — | — | CN | disclosed |
| CN-1424016-A | Oxidation composition containing specific aminosiloxane for treating keratin fibers | OREAL (FR) | 2003-06-18 | — | — | CN | disclosed |
| CN-1328595-A | Ceramer composition having abrasion and stain resistant characteristics | 3M INNOVATIVE PROPERTIES CO (US) | 2001-12-26 | — | — | CN | disclosed |