Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.45 |
| ▸ | RET | P07949 | 1/20 | 0.45 |
| ▸ | KIF5B | P33176 | 1/20 | 0.45 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.43 |
| ▸ | TUBB | P07437 | 1/20 | 0.43 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.43 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.43 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.43 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.43 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.43 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.43 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.43 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.43 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.43 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.43 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.43 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.43 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 2/20 | 0.40 |
| ▸ | RAF1 | P04049 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27582103 | 0.81 | KDR (0.40) | KDRRETKIF5BTUBB4ATUBB | |
| SCHEMBL27582076 | 0.75 | MAPT (0.49) | KDRRETKIF5BTUBB4ATUBB | |
| SCHEMBL27582043 | 0.75 | KDR (0.37) | KDRRETKIF5BBRAFRAF1 | |
| SCHEMBL27561352 | 0.73 | KDR (0.47) | KDRRETKIF5BTUBB4ATUBB | |
| SCHEMBL27582035 | 0.70 | P2RY4 (0.40) | KDRRETKIF5BMAPTALDH1A1 | |
| SCHEMBL8711337 | 0.67 | KDR (0.42) | KDRRETKIF5BTUBB4ATUBB | |
| SCHEMBL27582110 | 0.67 | KDR (0.35) | KDRRETMAPTALDH1A1EGFR | |
| SCHEMBL27564358 | 0.66 | PTGS1 (0.43) | MAPTALDH1A1MEN1GAAKMT2A | |
| SCHEMBL9645581 | 0.66 | CASP1 (0.58) | KDRRETKIF5BBRAFRAF1 | |
| SCHEMBL5154226 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1351498-A | Pyrrolotriazines inhibitors of kinases | BRISTOL MYERS SQUIBB CO (US) | 2002-05-29 | — | — | CN | claimed |