Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY4 | P51582 | 1/20 | 0.40 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 4/20 | 0.38 |
| ▸ | RET | P07949 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 3/20 | 0.36 |
| ▸ | KIF5B | P33176 | 1/20 | 0.36 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.35 |
| ▸ | CLK1 | P49759 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | TOP1 | P11387 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27561515 | 0.89 | EGFR (0.48) | EGFRRETMAPTALDH1A1MEN1 | |
| SCHEMBL27561352 | 0.82 | KDR (0.47) | EGFRRETMAPTALDH1A1MEN1 | |
| SCHEMBL27564358 | 0.82 | PTGS1 (0.43) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL27561385 | 0.78 | TDP1 (0.38) | MAPTALDH1A1KDM4EGLAGAA | |
| SCHEMBL27582103 | 0.78 | KDR (0.40) | EGFRRETMAPTALDH1A1MEN1 | |
| SCHEMBL27564357 | 0.78 | ALDH3A1 (0.46) | MAPTALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL27561393 | 0.77 | MAPT (0.55) | EGFRMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL27561403 | 0.74 | PTGS1 (0.40) | EGFRMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL27561674 | 0.74 | AR (0.36) | EGFRMAPTMEN1KMT2AKDM4E | |
| SCHEMBL27561375 | 0.73 | CA2 (0.42) | PTGS2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1351498-A | Pyrrolotriazines inhibitors of kinases | BRISTOL MYERS SQUIBB CO (US) | 2002-05-29 | — | — | CN | claimed |