Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A known ✓ | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.47 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.65 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.48 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | BPTF | Q12830 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | PANK3 | Q9H999 | 4/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6626896 | 0.89 | CHRNB2 (0.82) | CHRNB2CHRNA4LMNAHTTCHRNB4 | |
| SCHEMBL5036654 | 0.80 | CHRNB2 (1.00) | CHRNB2CHRNA4LMNAHTTCHRNB4 | |
| Hydrochloric Acid SCHEMBL2491811 | 0.79 | CHRNB2 (0.97) | CHRNB2CHRNA4LMNAHTTCHRNB4 | |
| Fumaric Acid SCHEMBL27601353 | 0.78 | BPTF (0.74) | CHRNB2CHRNA4LMNAHTTKMT2A | |
| Fumaric Acid SCHEMBL27491917 | 0.78 | LMNA (0.53) | CHRNB2CHRNA4LMNAHTTCHRNB4 | |
| Fumaric Acid SCHEMBL27470110 | 0.76 | BPTF (0.61) | CHRNB2CHRNA4LMNAHTTKMT2A | |
| SCHEMBL15379112 | 0.74 | LMNA (0.83) | CHRNB2CHRNA4LMNAHTTCHRNB4 | |
| SCHEMBL15379494 | 0.74 | LMNA (0.83) | CHRNB2CHRNA4LMNAHTTCHRNB4 | |
| SCHEMBL15379109 | 0.74 | LMNA (0.83) | CHRNB2CHRNA4LMNAHTTCHRNB4 | |
| Fumaric Acid SCHEMBL27501218 | 0.73 | BPTF (0.65) | LMNAHTTKMT2AMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1210277-C | Heteroaryl diazabicycloalkanes, their prepn. and use | NEUROSEARCH AS (DK) | 2005-07-13 | — | — | CN | disclosed |