Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 4/20 | 0.55 |
| ▸ | PPARG | P37231 | 3/20 | 0.55 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.54 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | PTGIR | P43119 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.48 |
| ▸ | CNR1 | P21554 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.46 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.46 |
| ▸ | PTGFR | P43088 | 1/20 | 0.45 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26206374 | 0.82 | PPARA (0.51) | PPARAPPARGCYSLTR2CYSLTR1MAPT | |
| SCHEMBL947863 | 0.81 | FFAR1 (0.67) | PPARAPPARGCYSLTR2CYSLTR1MAPT | |
| SCHEMBL17284879 | 0.81 | PPARA (0.77) | PPARAPPARGCYSLTR2CYSLTR1LMNA | |
| SCHEMBL1206751 | 0.81 | FOS (0.59) | PPARAPPARGFFAR1FOSJUN | |
| SCHEMBL28188589 | 0.80 | HDAC1 (0.70) | PPARAPPARGCYSLTR2CYSLTR1MAPT | |
| SCHEMBL1206248 | 0.80 | HDAC1 (0.70) | PPARAPPARGCYSLTR2CYSLTR1MAPT | |
| SCHEMBL28770237 | 0.80 | CYSLTR2 (0.47) | PPARAPPARGCYSLTR2CYSLTR1LMNA | |
| SCHEMBL27726083 | 0.80 | CYSLTR2 (0.47) | PPARAPPARGCYSLTR2CYSLTR1LMNA | |
| SCHEMBL23845448 | 0.80 | PPARA (0.50) | PPARAPPARGCYSLTR2CYSLTR1HDAC1 | |
| SCHEMBL26206366 | 0.79 | PPARA (0.47) | PPARAPPARGCYSLTR2CYSLTR1PTGIR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1325466-C | Calcilytic compounds | SMITHKLINE BEECHAM CORP (US) | 2007-07-11 | — | — | CN | disclosed |
| CN-1741985-A | Calcilytic compounds | SMITHKLINE BEECHAM CORP (US) | 2006-03-01 | — | — | CN | disclosed |