Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | NOS1 | P29475 | 3/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.39 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.38 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | REV1 | Q9UBZ9 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7681878 | 0.84 | ALDH1A1 (0.43) | ALDH1A1KDM4EARCYP1A1CYP1B1 | |
| SCHEMBL27566802 | 0.79 | ALDH1A1 (0.56) | ALDH1A1KDM4ENOS1CYP1A1CYP1B1 | |
| SCHEMBL27566803 | 0.78 | MAPT (0.38) | ALDH1A1KDM4EARMAPTTHRB | |
| SCHEMBL27518545 | 0.76 | BRD4 (0.36) | ALDH1A1KDM4ENOS1MAPTLMNA | |
| SCHEMBL7688735 | 0.73 | MAPT (0.41) | ALDH1A1KDM4EARMAPTKMT2A | |
| SCHEMBL17386575 | 0.67 | MAPT (0.49) | ALDH1A1KDM4EMAPTKMT2ASMN1; SMN2 | |
| SCHEMBL8275696 | 0.67 | NOS1 (0.67) | ALDH1A1NOS1KMT2AMEN1 | |
| SCHEMBL2761914 | 0.66 | TAAR1 (0.56) | MAPTGAA | |
| SCHEMBL8893338 | 0.64 | ALDH1A1 (0.65) | ALDH1A1KDM4ECYP1A1CYP1B1MAPT | |
| SCHEMBL7684369 | 0.64 | ALDH1A1 (0.60) | ALDH1A1KDM4ENOS1CYP1A1CYP1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1276790-A | Carboxamidothiazole derivs., preparation, pharmaceutical composition contg. them | SANOFI SA (FR) | 2000-12-13 | — | — | CN | disclosed |