Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR88 | Q9GZN0 | 2/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.42 |
| ▸ | XDH | P47989 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | FOS | P01100 | 1/20 | 0.36 |
| ▸ | JUN | P05412 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.36 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27734033 | 0.86 | ALDH1A1 (0.45) | MEN1KMT2ATP53MAPTALDH1A1 | |
| SCHEMBL27546842 | 0.83 | GPR88 (0.47) | GPR88HIF1AXDHMEN1KMT2A | |
| SCHEMBL27546834 | 0.75 | ADRA1A (0.54) | MEN1KMT2AMAPTTSHRHTT | |
| SCHEMBL27598847 | 0.74 | POLB (0.49) | KMT2ASMN1; SMN2HTTALDH1A1 | |
| SCHEMBL11045547 | 0.73 | CA2 (0.57) | HIF1AXDHKDM4ESMN1; SMN2MAPT | |
| SCHEMBL4687529 | 0.72 | PARP15 (0.59) | HIF1AXDHTP53SMN1; SMN2HTT | |
| SCHEMBL11132563 | 0.69 | ALDH1A1 (0.59) | XDHKDM4EMEN1KMT2AMAPT | |
| SCHEMBL13877387 | 0.69 | HIF1A (0.47) | HIF1AKDM4EMEN1KMT2ATP53 | |
| SCHEMBL27916444 | 0.69 | POLB (0.41) | SMN1; SMN2USP2ALDH1A1 | |
| SCHEMBL31688947 | 0.69 | AKR1C3 (0.60) | TP53ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1325462-C | Novel substituted arylhexadienoic acids and esters thereof which can be used for the treatment and prevention of diabetes, dyslipidaemia and atherosclerosis, pharmaceutical compositions comprising the | MERCK PATENT GMBH (DE) | 2007-07-11 | — | — | CN | disclosed |
| CN-1688534-A | Novel substituted arylhexadienoic acids and esters thereof which can be used for the treatment and prevention of diabetes, dyslipidaemia and atherosclerosis, pharmaceutical compositions comprising the | MERCK PATENT GMBH (DE) | 2005-10-26 | — | — | CN | disclosed |