Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA4 | P48058 | 4/20 | 0.35 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.30 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.30 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2645256 | 0.72 | TSHR (0.33) | LMNAHPGDTSHRPIK3CDPIK3CA | |
| SCHEMBL27466732 | 0.72 | HDAC8 (0.41) | — | |
| SCHEMBL27466234 | 0.69 | GCK (0.33) | GRIA4 | |
| SCHEMBL2646368 | 0.65 | HSP90AA1 (0.43) | LMNAPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL30085302 | 0.65 | HSP90AA1 (0.43) | LMNAPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL15478494 | 0.63 | L3MBTL1 (0.44) | LMNATSHRPIK3CDPIK3CAPIK3CB | |
| SCHEMBL7017664 | 0.63 | ALDH1A3 (0.46) | HPGDTSHRPIK3CDPIK3CAPIK3CB | |
| SCHEMBL27502624 | 0.63 | PIK3CD (0.33) | PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL23001810 | 0.62 | ENPP2 (0.45) | LMNAHPGDPIK3CDPIK3CAPIK3CB | |
| SCHEMBL12496190 | 0.62 | L3MBTL1 (0.62) | HPGDTSHRPIK3CDPIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1226294-C | Fused heteroaromatic glucokinase activators | HOFFMANN LA ROCHE (CH) | 2005-11-09 | — | — | CN | disclosed |
| CN-1476438-A | Fused heteroaromatic glucokinase activators | - | 2004-02-18 | — | — | CN | disclosed |