Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.36 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.36 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | KLK7 | P49862 | 1/20 | 0.35 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.35 |
| ▸ | TGM2 | P21980 | 6/20 | 0.34 |
| ▸ | FOLH1 | Q04609 | 3/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL277624 | 0.88 | SIRT2 (0.38) | SIRT2SIRT1SIRT3KLK7KLK5 | |
| SCHEMBL10017795 | 0.88 | EPHX1 (0.38) | SIRT2SIRT1SIRT3CA1CA2 | |
| SCHEMBL327848 | 0.88 | EPHX1 (0.38) | SIRT2SIRT1SIRT3CA1CA2 | |
| SCHEMBL12990568 | 0.87 | HPGD (0.35) | SIRT2SIRT1SIRT3CA1CA2 | |
| SCHEMBL13167106 | 0.86 | ACE (0.36) | SIRT2SIRT1SIRT3CA1CA2 | |
| SCHEMBL13339221 | 0.85 | SIRT2 (0.35) | SIRT2SIRT1SIRT3KLK7KLK5 | |
| SCHEMBL12509746 | 0.85 | SIRT1 (0.38) | SIRT2SIRT1SIRT3CA1CA2 | |
| SCHEMBL12508324 | 0.84 | EPHX1 (0.36) | SIRT2SIRT1SIRT3CA1CA2 | |
| SCHEMBL12694367 | 0.84 | FOLH1 (0.39) | SIRT2SIRT1SIRT3CA1CA2 | |
| SCHEMBL3754005 | 0.82 | TDP1 (0.48) | CA1CA2KLK7KLK5ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120302761-A1 | INTERMEDIATES USEFUL IN THE PREPARATION OF MALEIMIDE FUNCTIONALIZED POLYMERS | NEKTAR THERAPEUTICS (US) | 2012-11-29 | — | — | US | disclosed |
| US-8258324-B2 | Intermediates useful in the preparation of maleimide functionalized polymers | NEKTAR THERAPEUTICS (US) | 2012-09-04 | — | — | US | disclosed |
| US-20120004422-A1 | Intermediates Useful in the Preparation of Maleimide Functionalized Polymers | NEKTAR THERAPEUTICS (US) | 2012-01-05 | — | — | US | disclosed |
| US-7790835-B2 | Water soluble, non-peptidic polymer covalently attached to a Diels-Alder bicyclic or tricyclic imide ring; chemical intermediates | NEKTAR THERAPEUTICS (US) | 2010-09-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120302761-A1 | INTERMEDIATES USEFUL IN THE PREPARATION OF MALEIMIDE FUNCTIONALIZED POLYMERS | DERA, MMAB, PAICS | SIRT2 1300/4885SIRT1 1247/4885SIRT3 869/4885 |
| US-20120004422-A1 | Intermediates Useful in the Preparation of Maleimide Functionalized Polymers | DERA, MMAB, PAICS | SIRT2 1300/4885SIRT1 1247/4885SIRT3 869/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.