Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.36 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.36 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | KLK7 | P49862 | 1/20 | 0.35 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.35 |
| ▸ | TGM2 | P21980 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | ABHD16A | O95870 | 1/20 | 0.33 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.33 |
| ▸ | NCEH1 | Q6PIU2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10017795 | 1.00 | EPHX1 (0.38) | EPHX1SIRT2SIRT1SIRT3TDP1 | |
| SCHEMBL12508324 | 0.96 | EPHX1 (0.36) | EPHX1SIRT2SIRT1SIRT3TDP1 | |
| SCHEMBL12509746 | 0.94 | SIRT1 (0.38) | EPHX1SIRT2SIRT1SIRT3TDP1 | |
| SCHEMBL13167106 | 0.93 | ACE (0.36) | EPHX1SIRT2SIRT1SIRT3TDP1 | |
| SCHEMBL12694367 | 0.93 | FOLH1 (0.39) | SIRT2SIRT1SIRT3TDP1ATM | |
| SCHEMBL2756775 | 0.88 | SIRT2 (0.36) | SIRT2SIRT1SIRT3TDP1ATM | |
| SCHEMBL277624 | 0.88 | SIRT2 (0.38) | SIRT2SIRT1SIRT3KLK7KLK5 | |
| SCHEMBL12508619 | 0.87 | SIRT2 (0.31) | SIRT2SIRT1SIRT3 | |
| SCHEMBL29400712 | 0.86 | TDP1 (0.48) | TDP1ATMCA1CA2KLK7 | |
| SCHEMBL3754005 | 0.86 | TDP1 (0.48) | TDP1ATMCA1CA2KLK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 119 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180051287-A1 | COMPOSITIONS AND METHODS FOR INHIBITING FACTOR D | CALW INVESTMENT CO. INC. (CA) | 2018-02-22 | — | — | US | disclosed |
| US-9763995-B2 | Polymer conjugates of protegrin peptides | NEKTAR THERAPEUTICS (US) | 2017-09-19 | — | — | US | disclosed |
| US-20170196975-A1 | CONJUGATES OF AN ANTI-TNF-ALPHA ANTIBODY | NEKTAR THERAPEUTICS | 2017-07-13 | — | — | US | disclosed |
| US-9682153-B2 | Polymer conjugates of therapeutic peptides | NEKTAR THERAPEUTICS (US) | 2017-06-20 | — | — | US | disclosed |
| US-20170035896-A1 | POLYMER FACTOR IX MOIETY CONJUGATES | NEKTAR THERAPEUTICS | 2017-02-09 | — | — | US | disclosed |
| US-20170035898-A1 | CONJUGATES OF AN IL-15 MOIETY AND A POLYMER | NEKTAR THERAPEUTICS | 2017-02-09 | — | — | US | disclosed |
| US-9539337-B2 | Compositions comprising two different populations of polymer-active agent conjugates | NEKTAR THERAPEUTICS (US) | 2017-01-10 | — | — | US | disclosed |
| US-9446139-B2 | Polymer-based compositions and conjugates of HIV entry inhibitors | NEKTAR THERAPEUTICS (US) | 2016-09-20 | — | — | US | disclosed |
| US-9433684-B2 | Conjugates of small-interfering nucleic acids | NEKTAR THERAPEUTICS (US) | 2016-09-06 | — | — | US | disclosed |
| US-9421275-B2 | Oligomer-calcimimetic conjugates and related compunds | NEKTAR THERAPEUTICS (US) | 2016-08-23 | — | — | US | disclosed |
| US-7419600-B2 | Method for purifying a branched water-soluble polymer | NEKTAR THERAPEUTICS AL, CORPORATION (US) | 2008-09-02 | — | — | US | disclosed |
| US-20080125383-A1 | For host undergoing surgery or coronary artery bypass | TOBIRA THERAPEUTICS, INC. | 2008-05-29 | — | — | US | disclosed |
| US-7365127-B2 | Process for the preparation of polymer conjugates | ENZON PHARMACEUTICALS, INC. (US) | 2008-04-29 | — | — | US | disclosed |
| US-20080058504-A1 | Water soluble polyoxyethylene glylcol polyvinylpyrrolidone, polyvinyl alcohol, polyoxazoline, and/or polyacryloylmorpholine, conjugated to antihemophilic factor | NEKTAR THERAPEUTICS | 2008-03-06 | — | — | US | disclosed |
| US-20070166277-A1 | Polymeric reagents comprising a ketone or a related functional group | NEKTAR THERAPEUTICS | 2007-07-19 | — | — | US | disclosed |
| US-20070105809-A1 | Modulators of coagulation factors with enhanced stability | REGADO BIOSCIENCES, INC. | 2007-05-10 | — | — | US | disclosed |
| US-20070092482-A1 | Conjugates of a G-CSF moiety and a polymer | NEKTAR THERAPEUTICS | 2007-04-26 | — | — | US | disclosed |
| US-7208145-B2 | Useful for providing conjugates with other substances | NEKTAR THERAPEUTICS AL, CORPORATION (US) | 2007-04-24 | — | — | US | disclosed |
| US-7199223-B2 | Water soluble polyoxyethylene glylcol polyvinylpyrrolidone, polyvinyl alcohol, polyoxazoline, and/or polyacryloylmorpholine, conjugated to antihemophilic factor | NEKTAR THERAPEUTICS AL, CORPORATION (US) | 2007-04-03 | — | — | US | disclosed |
| US-20070031371-A1 | Method for Preparing Branched Functionalized Polymers Using Branched Polyol Cores | NEKTAR THERAPEUTICS AL, CORPORATION | 2007-02-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070166277-A1 | Polymeric reagents comprising a ketone or a related functional group | TKT, KHK, KLK5 | EPHX1 608/4885SIRT2 722/4885SIRT1 318/4885 |
| US-20170035896-A1 | POLYMER FACTOR IX MOIETY CONJUGATES | F9, F13A1, F8 | EPHX1 459/4885SIRT2 4162/4885SIRT1 3966/4885 |
| US-20170196975-A1 | CONJUGATES OF AN ANTI-TNF-ALPHA ANTIBODY | TNF, TNFRSF1A, TNFRSF9 | EPHX1 1328/4885SIRT2 4032/4885SIRT1 3515/4885 |
| US-20070092482-A1 | Conjugates of a G-CSF moiety and a polymer | CSF3R, GMFG, CSF1R | EPHX1 2439/4885SIRT2 4032/4885SIRT1 3894/4885 |
| US-20080058504-A1 | Water soluble polyoxyethylene glylcol polyvinylpyrrolidone, polyvinyl alcohol, polyoxazoline, and/or polyacryloylmorpholine, conjugated to antihemophilic factor | F8, F13A1, F13B | EPHX1 2395/4885SIRT2 4490/4885SIRT1 4397/4885 |
| US-20080125383-A1 | For host undergoing surgery or coronary artery bypass | NSUN2, SERPINC1, NSUN3 | EPHX1 2937/4885SIRT2 2495/4885SIRT1 2152/4885 |
| US-20070031371-A1 | Method for Preparing Branched Functionalized Polymers Using Branched Polyol Cores | PARG, VIP, PHYKPL | EPHX1 2764/4885SIRT2 3354/4885SIRT1 3618/4885 |
| US-20070105809-A1 | Modulators of coagulation factors with enhanced stability | SERPINC1, TFPI, F13B | EPHX1 3423/4885SIRT2 1913/4885SIRT1 1729/4885 |
| US-20170035898-A1 | CONJUGATES OF AN IL-15 MOIETY AND A POLYMER | IL15, IL15RA, IL2 | EPHX1 2196/4885SIRT2 2813/4885SIRT1 2294/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.