Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.35 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.34 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.34 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.34 |
| ▸ | ACE | P12821 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 7/20 | 0.34 |
| ▸ | TGM2 | P21980 | 1/20 | 0.33 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | EP300 | Q09472 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL277624 | 0.96 | SIRT2 (0.38) | SIRT2SIRT1HDAC4ACETGM2 | |
| SCHEMBL13167106 | 0.92 | ACE (0.36) | SIRT2SIRT1HDAC4HDAC3HDAC1 | |
| SCHEMBL12692567 | 0.89 | SIRT2 (0.41) | SIRT2SIRT1HDAC4HDAC3HDAC1 | |
| SCHEMBL12424727 | 0.89 | ACE (0.36) | SIRT2SIRT1HDAC4HDAC3HDAC1 | |
| SCHEMBL12508324 | 0.88 | EPHX1 (0.36) | SIRT2SIRT1TGM2SIRT3KMT2A | |
| SCHEMBL2756775 | 0.85 | SIRT2 (0.36) | SIRT2SIRT1TGM2SIRT3KMT2A | |
| SCHEMBL10017795 | 0.84 | EPHX1 (0.38) | SIRT2SIRT1TGM2SIRT3KMT2A | |
| SCHEMBL327848 | 0.84 | EPHX1 (0.38) | SIRT2SIRT1TGM2SIRT3KMT2A | |
| SCHEMBL30895563 | 0.83 | MEN1 (0.48) | ACEKMT2AKLK7KLK5 | |
| SCHEMBL12604209 | 0.83 | MEN1 (0.48) | ACEKMT2AKLK7KLK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110171166-A1 | POLYMER CONJUGATES OF OSTEOCALCIN PEPTIDES | NEKTAR THERAPEUTICS | 2011-07-14 | — | — | US | disclosed |
| US-20100130684-A1 | POLYMER FACTOR IX MOIETY CONJUGATES | NEKTAR THERAPEUTICS (US) | 2010-05-27 | — | — | US | disclosed |
| US-7714114-B2 | Conjugates of an EPO moiety and a polymer | NEKTAR THERAPEUTICS (US) | 2010-05-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100130684-A1 | POLYMER FACTOR IX MOIETY CONJUGATES | F9, F13A1, F8 | SIRT2 4162/4885SIRT1 3966/4885HDAC4 3492/4885 |
| US-20110171166-A1 | POLYMER CONJUGATES OF OSTEOCALCIN PEPTIDES | SOST, PTMS, ALPP | SIRT2 2572/4885SIRT1 1581/4885HDAC4 3678/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.