Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 2/20 | 0.39 |
| ▸ | SIRT1 | Q96EB6 | 3/20 | 0.35 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.35 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.35 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TGM2 | P21980 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 3/20 | 0.32 |
| ▸ | CA2 | P00918 | 3/20 | 0.32 |
| ▸ | ALB | P02768 | 3/20 | 0.32 |
| ▸ | KLK7 | P49862 | 1/20 | 0.32 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL327848 | 0.93 | EPHX1 (0.38) | FOLH1SIRT1SIRT2SIRT3TGM2 | |
| SCHEMBL10017795 | 0.93 | EPHX1 (0.38) | FOLH1SIRT1SIRT2SIRT3TGM2 | |
| SCHEMBL10328000 | 0.93 | FOLH1 (0.42) | FOLH1SIRT1SIRT6SIRT5KDM4E | |
| SCHEMBL12509746 | 0.92 | SIRT1 (0.38) | FOLH1SIRT1SIRT6SIRT5SIRT2 | |
| SCHEMBL12508324 | 0.89 | EPHX1 (0.36) | SIRT1SIRT2SIRT3SMN1; SMN2TGM2 | |
| SCHEMBL13167106 | 0.88 | ACE (0.36) | FOLH1SIRT1SIRT2SIRT3TGM2 | |
| SCHEMBL13901992 | 0.86 | SIRT6 (0.46) | FOLH1SIRT1SIRT6SIRT5KDM4E | |
| SCHEMBL12508619 | 0.85 | SIRT2 (0.31) | SIRT1SIRT2SIRT3 | |
| SCHEMBL2756775 | 0.84 | SIRT2 (0.36) | FOLH1SIRT1SIRT2SIRT3TGM2 | |
| SCHEMBL277624 | 0.83 | SIRT2 (0.38) | FOLH1SIRT1SIRT2SIRT3TGM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120245289-A1 | POLYMER-FACTOR VIII MOIETY CONJUGATES | NEKTAR THERAPEUTICS (US) | 2012-09-27 | — | — | US | disclosed |
| US-20070105809-A1 | Modulators of coagulation factors with enhanced stability | REGADO BIOSCIENCES, INC. | 2007-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120245289-A1 | POLYMER-FACTOR VIII MOIETY CONJUGATES | F8, F9, F13B | FOLH1 220/4885SIRT1 4382/4885SIRT6 3095/4885 |
| US-20070105809-A1 | Modulators of coagulation factors with enhanced stability | SERPINC1, TFPI, F13B | FOLH1 1442/4885SIRT1 1729/4885SIRT6 1258/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.