Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.48 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.44 |
| ▸ | ABCG2 | Q9UNQ0 | 6/20 | 0.44 |
| ▸ | CDK4 | P11802 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | F9 | P00740 | 1/20 | 0.41 |
| ▸ | ACP1 | P24666 | 1/20 | 0.40 |
| ▸ | STK10 | O94804 | 1/20 | 0.40 |
| ▸ | CLK2 | P49760 | 1/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2976781 | 0.77 | DHPS (0.48) | EGFRSLC2A1ABCG2ABCB1ABCC1 | |
| SCHEMBL27561547 | 0.76 | RAPGEF4 (0.51) | EGFRABCG2ALDH1A1GAAMAPT | |
| SCHEMBL30679771 | 0.76 | SLC2A1 (0.67) | EGFRSLC2A1ABCG2ALDH1A1KDM4E | |
| SCHEMBL21436780 | 0.76 | SLC2A1 (0.67) | EGFRSLC2A1ABCG2ALDH1A1KDM4E | |
| SCHEMBL953597 | 0.76 | ALDH1A1 (0.56) | EGFRSLC2A1ABCG2ALDH1A1MAPT | |
| SCHEMBL27561674 | 0.76 | AR (0.36) | EGFRABCG2KDM4EGAAMAPT | |
| SCHEMBL30619678 | 0.74 | NPSR1 (0.60) | EGFRSLC2A1ABCG2ALDH1A1MAPT | |
| SCHEMBL21439863 | 0.74 | NPSR1 (0.60) | EGFRSLC2A1ABCG2ALDH1A1MAPT | |
| SCHEMBL27561679 | 0.74 | LRRK2 (0.36) | ABCG2CDK4CDK2ALDH1A1KDM4E | |
| SCHEMBL27561396 | 0.73 | ABCG2 (0.44) | ABCG2ALDH1A1PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1351498-B | Pyrrolotriazines inhibitors of kinases | BRISTOL MYERS SQUIBB CO | 2012-08-15 | — | — | CN | claimed |
| CN-1351498-A | Pyrrolotriazines inhibitors of kinases | BRISTOL MYERS SQUIBB CO (US) | 2002-05-29 | — | — | CN | claimed |
| CN-1351498-B | Pyrrolotriazines inhibitors of kinases | BRISTOL MYERS SQUIBB CO | 2012-08-15 | — | — | CN | disclosed |
| CN-1351498-A | Pyrrolotriazines inhibitors of kinases | BRISTOL MYERS SQUIBB CO (US) | 2002-05-29 | — | — | CN | disclosed |