Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | HPGD | P15428 | 5/20 | 0.48 |
| ▸ | GLA | P06280 | 4/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | TNKS2 | Q9H2K2 | 8/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.41 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15159310 | 0.76 | AR (0.65) | KDM4EALDH1A1HPGDGLAGAA | |
| SCHEMBL31331891 | 0.75 | TNKS2 (0.66) | KDM4EALDH1A1HPGDGLAGAA | |
| SCHEMBL27564358 | 0.74 | PTGS1 (0.43) | KDM4EALDH1A1HPGDGAATP53 | |
| SCHEMBL14399200 | 0.71 | HPGD (0.63) | KDM4EALDH1A1HPGDGLAGAA | |
| SCHEMBL27564357 | 0.70 | ALDH3A1 (0.46) | ALDH1A1TP53SMN1; SMN2LMNAKMT2A | |
| SCHEMBL27561403 | 0.70 | PTGS1 (0.40) | KDM4EALDH1A1TP53CYP2C19CYP1A2 | |
| SCHEMBL27561385 | 0.70 | TDP1 (0.38) | KDM4EALDH1A1GLAGAASMN1; SMN2 | |
| SCHEMBL27582103 | 0.70 | KDR (0.40) | ALDH1A1GAACYP2C19CYP1A2CYP3A4 | |
| SCHEMBL14193711 | 0.70 | KDM4E (0.55) | KDM4EALDH1A1HPGDGLAGAA | |
| SCHEMBL27561363 | 0.70 | EGFR (0.54) | KDM4EALDH1A1HPGDGLASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1351498-B | Pyrrolotriazines inhibitors of kinases | BRISTOL MYERS SQUIBB CO | 2012-08-15 | — | — | CN | claimed |
| CN-1351498-B | Pyrrolotriazines inhibitors of kinases | BRISTOL MYERS SQUIBB CO | 2012-08-15 | — | — | CN | disclosed |
| CN-1351498-A | Pyrrolotriazines inhibitors of kinases | BRISTOL MYERS SQUIBB CO (US) | 2002-05-29 | — | — | CN | disclosed |