Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 13/20 | 0.50 |
| ▸ | CA1 | P00915 | 12/20 | 0.50 |
| ▸ | CA9 | Q16790 | 5/20 | 0.50 |
| ▸ | CA12 | O43570 | 3/20 | 0.50 |
| ▸ | CA6 | P23280 | 1/20 | 0.50 |
| ▸ | CA5A | P35218 | 1/20 | 0.50 |
| ▸ | CA7 | P43166 | 1/20 | 0.50 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.50 |
| ▸ | PTGES2 | Q9H7Z7 | 6/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27561375 | 0.76 | CA2 (0.42) | CA2CA1CA9CA12CA7 | |
| SCHEMBL27561508 | 0.72 | POLB (0.47) | CA2CA1CA9CA12 | |
| SCHEMBL27576857 | 0.71 | LMNA (0.34) | CA2CA1CA9CA12 | |
| SCHEMBL1127421 | 0.71 | CA2 (0.62) | CA2CA1CA9CA12CA6 | |
| SCHEMBL20766620 | 0.71 | CA2 (0.62) | CA2CA1CA9CA12CA6 | |
| SCHEMBL3363295 | 0.70 | CA2 (0.67) | CA2CA1CA9CA12CA6 | |
| SCHEMBL30335715 | 0.70 | CA2 (0.67) | CA2CA1CA9CA12CA6 | |
| SCHEMBL7778935 | 0.70 | CA2 (0.47) | CA2CA1CA9CA12CA6 | |
| SCHEMBL27561408 | 0.69 | RET (0.40) | — | |
| SCHEMBL1425352 | 0.68 | CA2 (1.00) | CA2CA1CA9CA12CA6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1351498-B | Pyrrolotriazines inhibitors of kinases | BRISTOL MYERS SQUIBB CO | 2012-08-15 | — | — | CN | claimed |
| CN-1351498-A | Pyrrolotriazines inhibitors of kinases | BRISTOL MYERS SQUIBB CO (US) | 2002-05-29 | — | — | CN | claimed |
| CN-1351498-B | Pyrrolotriazines inhibitors of kinases | BRISTOL MYERS SQUIBB CO | 2012-08-15 | — | — | CN | disclosed |
| CN-1351498-A | Pyrrolotriazines inhibitors of kinases | BRISTOL MYERS SQUIBB CO (US) | 2002-05-29 | — | — | CN | disclosed |